Title:
【発明の名称】タキサン誘導体の新規製造法、かくして得られる新規誘導体及びそれらを含む組成物
Document Type and Number:
Japanese Patent JPH08503486
Kind Code:
A
Abstract:
PCT No. PCT/FR93/01145 Sec. 371 Date May 23, 1995 Sec. 102(e) Date May 23, 1995 PCT Filed Nov. 22, 1993 PCT Pub. No. WO94/12484 PCT Pub. Date Jun. 9, 1994This invention relates to a method for the preparation of taxane derivatives having the formula (I) and pharmaceutical compositions which contain the derivatives thus obtained. In formula (I), R is hydrogen or acetyl, R1 is benzoyl or R2-O-CO wherein R2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl and Het is a 5-membered optionally substituted aromatic heterocycle (thiophene, tiazole, furan, pyrrole, imidazole, oxazole, isoxazole, pyrazole). The products of formula (I) have remarkable antitumor and antileukemia properties. (I)
Inventors:
Bouchard, Elbe
Burza, Jiyan-Dominique
Amerin, Commerson
Burza, Jiyan-Dominique
Amerin, Commerson
Application Number:
JP51284194A
Publication Date:
April 16, 1996
Filing Date:
November 22, 1993
Export Citation:
Assignee:
Loan-Poulin L'Oré Societe Anonym
International Classes:
C07D305/14; A61K31/335; A61K31/337; A61K31/34; A61K31/41; A61K31/415; A61K31/425; A61P35/00; A61P35/02; C07D405/12; C07D407/12; C07D409/12; C07D413/12; C07D417/12; (IPC1-7): C07D405/12; A61K31/335; A61K31/34; A61K31/41; A61K31/415; A61K31/425; C07D305/14; C07D405/12; C07D407/12; C07D409/12; C07D413/12; C07D417/12
Attorney, Agent or Firm:
Heiyoshi Odashima