Title:
遷移金属を触媒とする炭素-窒素結合および炭素-炭素結合形成反応
Document Type and Number:
Japanese Patent JP5244399
Kind Code:
B2
Abstract:
One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.
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Inventors:
Batchwold, Stephan El
Anderson, Kevin W
Anderson, Kevin W
Application Number:
JP2007550475A
Publication Date:
July 24, 2013
Filing Date:
January 09, 2006
Export Citation:
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
International Classes:
C07F9/50; C07C1/32; C07C15/14; C07C41/30; C07C43/215; C07C51/353; C07C59/68; C07C63/04; C07C63/10; C07C63/14; C07C63/331; C07C65/105; C07C65/30; C07C65/34; C07C227/16; C07C229/54; C07C229/62; C07C231/14; C07C233/65; C07C253/30; C07C255/57; C07C303/22; C07C303/40; C07C309/30; C07C311/16; C07D209/40; C07D213/22; C07D213/80; C07D327/08; C07D409/04; C07B61/00
Foreign References:
| WO2004052939A2 | ||||
| WO2000002887A2 |
Other References:
DEVASHER,R.B. et al.,Aqueous-phase, palladium-catalyzed cross-coupling of aryl bromides under mild conditions, using water-soluble, sterically demanding alkylphosphines,Journal of the Organic Chemistry,2004年,Vol.69,p.7919-7927
WULLNER,G. et al.,Palladium-catalyzed amination of aromatic halides in water-containing solvent systems: a two-phase protocol,Chemical Communications,1998年,p.1509-1510
HERD,O. et al.,Water-soluble phosphines. 17. Novel water-soluble secondary and tertiary phosphines with disulfonated 1,1'-biphenyl backbones and dibenzophosphole moieties,Inorganic Chemistry,2002年,Vol.41,p.5034-5042
BARDER,T.E. and BUCHWALD,S.L.,Efficient catalyst for the Suzuki-Miyaura coupling of potassium aryl trifluoroborates with aryl chlorides,Organic Letters,2004年,Vol.6, No.16,p.2649-2652
WULLNER,G. et al.,Palladium-catalyzed amination of aromatic halides in water-containing solvent systems: a two-phase protocol,Chemical Communications,1998年,p.1509-1510
HERD,O. et al.,Water-soluble phosphines. 17. Novel water-soluble secondary and tertiary phosphines with disulfonated 1,1'-biphenyl backbones and dibenzophosphole moieties,Inorganic Chemistry,2002年,Vol.41,p.5034-5042
BARDER,T.E. and BUCHWALD,S.L.,Efficient catalyst for the Suzuki-Miyaura coupling of potassium aryl trifluoroborates with aryl chlorides,Organic Letters,2004年,Vol.6, No.16,p.2649-2652
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma