Title:
Ｎ−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法
Document Type and Number:
Japanese Patent JP5818237
Kind Code:
B2
Abstract:
A method for screening a non-standard peptide compound in the peptide library that binds to the target substance, comprising the steps: (i) preparing a non-standard peptide library wherein a special (non-standard) amino acid is randomly incorporated into the peptide sequence by a cell-free ( in vitro ) translation system comprising a tRNA acylated by a special (non-standard) amino acid; (ii) bringing the obtained peptide library in contact with a target substance; and (iii) selecting a non-standard peptide that binds to the target substance as an active peptide.
Inventors:
Hiroaki Suga
Yusuke Yamagishi
Yusuke Yamagishi
Application Number:
JP2010202012A
Publication Date:
November 18, 2015
Filing Date:
September 09, 2010
Export Citation:
Assignee:
National University Corporation Tokyo University
International Classes:
G01N33/50; C40B40/08; C40B40/10; G01N33/566
Foreign References:
| WO2008059823A1 | ||||
| WO2008117833A1 |
Other References:
林剛介,特殊環状ペプチドの翻訳合成と医薬品探索への展開,生化学,2010年 6月25日,Vol.82/No.6,pp.505-514
樋口岳,擬天然物特殊ペプチドのプログラム翻訳合成と応用,有機合成化学協会誌,2010年 3月 1日,Vol.68/No.3,pp.217-227
樋口岳,擬天然物特殊ペプチドのプログラム翻訳合成と応用,有機合成化学協会誌,2010年 3月 1日,Vol.68/No.3,pp.217-227
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Akiko Nakahama
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Akiko Nakahama