Title:
微小管安定化剤を用いたアテローム性動脈硬化症または再狭窄症の治療方法
Document Type and Number:
Japanese Patent JP4615478
Kind Code:
B2
Abstract:
The present invention is a method of preventing or reducing atherosclerosis or restenosis, and a pharmaceutical preparation used therefore. In particular, it is a method of preventing or reducing atherosclerosis or restenosis after arterial injury by treatment with a low dose of a microtubule stabilizing agent such as taxol or a water soluble taxol derivative. The low dose used in the present invention prevents artery blockage while minimizing any negative side effects associated with the drug.
Inventors:
Kinsella, James El
Stephen Jay, Solot
Stephen Jay, Solot
Application Number:
JP2006128856A
Publication Date:
January 19, 2011
Filing Date:
May 08, 2006
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
A61K31/337; C07D305/14; A61K31/335; A61L31/00; A61L31/16; A61P9/00; A61P9/10; A61K9/00
Domestic Patent References:
| JP5502179A | ||||
| JP3505725A | ||||
| JP9503488A |
Foreign References:
| WO1993011120A1 | ||||
| US5157049 |
Other References:
J. MICROENCAPSULATION,1990年,7(2),191-197
‘THE MERCK INDEX’,MERCK CO.INC.,1989年,P.1435 「9049. Taxol」の項
EUROPEAN JOURNAL OF CELL BIOLOGY,1990年,51,303-312
EUROPEAN JOURNAL OF CELL BIOLOGY,1992年,58,365-370
CIRCULATION,1989年,80 (SUPPL. II), P.II-66 0263
EXP. MOL. PATHOL.,1988年,48(1),48-58
ATHEROSCLEROSIS,1982年,44,385-390
‘THE MERCK INDEX’,MERCK CO.INC.,1989年,P.1435 「9049. Taxol」の項
EUROPEAN JOURNAL OF CELL BIOLOGY,1990年,51,303-312
EUROPEAN JOURNAL OF CELL BIOLOGY,1992年,58,365-370
CIRCULATION,1989年,80 (SUPPL. II), P.II-66 0263
EXP. MOL. PATHOL.,1988年,48(1),48-58
ATHEROSCLEROSIS,1982年,44,385-390
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya