Title:
超臨界的流体による処理方法:タンパク質微粒子の調製およびそれらの安定化
Document Type and Number:
Japanese Patent JP4374249
Kind Code:
B2
Abstract:
A coprecipitate of protein or polypeptide and stabiliser obtained by a process for the co-precipitation of a substance with a stabiliser therefor, by a gas anti solvent process comprising introducing into a particle formation vessel a supercritical fluid pure or mixed with a modifier; and a solution comprising said substance and said stabiliser dissolved in a solvent; so as said solvent is extracted from the solution by said supercritical fluid and co-precipitation of the substance and stabiliser occurs. The process may be carried out using an apparatus comprising a particle formation vessel and a nozzle having a central orifice serving to introduce a solution of the substance and a plurality of outer orifices serving to carry a flow of supercritical fluid into the particle formation vessel, such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron sized particles of the substance/stabiliser occurs.
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Inventors:
Gentile, Marco
Di Palma, Cesare
Chester, Maria, Candida
Di Palma, Cesare
Chester, Maria, Candida
Application Number:
JP2003538186A
Publication Date:
December 02, 2009
Filing Date:
October 21, 2002
Export Citation:
Assignee:
Don PPE H.A.R.M.A.S.P.A.
International Classes:
C07K1/32; C07K1/30; C12N9/96
Domestic Patent References:
| JP9503394A |
Foreign References:
| WO2000052037A1 |
Other References:
J. Controll. Release, vol. 24, pages 27-44 (1993)
FORD A W DAWSON P J,JOURNAL OF PHARMACY AND PHARMACOLOGY,英国,1993年,V45 N2,P86-93
FORD A W DAWSON P J,JOURNAL OF PHARMACY AND PHARMACOLOGY,英国,1993年,V45 N2,P86-93
Attorney, Agent or Firm:
Ikeuchi, Sato & Partners