Title:
TRIARYL METHANE COMPOUND FOR SICKLE CELL DISEASE
Document Type and Number:
Japanese Patent JP2008201783
Kind Code:
A
Abstract:
To provide a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation.
The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups are replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. The compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle cell dehydration and/or delay the occurrence of erythrocyte sickling or deformation.
Inventors:
BRUGNARA CARLO
HALPERIN JOSE
BELLOT EMILE M JR
FROIMOWITZ MARK
LOMBARDY RICHARD J
CLIFFORD JOHN J
GAO YING-DUO
HAIDAR REEM M
KELLEHER EUGENE W
KHER FALGUNI M
MOUSSA ADEL M
SACHDEVA YESH P
SUN MINGHUA
TAFT HEATHER N
HALPERIN JOSE
BELLOT EMILE M JR
FROIMOWITZ MARK
LOMBARDY RICHARD J
CLIFFORD JOHN J
GAO YING-DUO
HAIDAR REEM M
KELLEHER EUGENE W
KHER FALGUNI M
MOUSSA ADEL M
SACHDEVA YESH P
SUN MINGHUA
TAFT HEATHER N
Application Number:
JP2008048469A
Publication Date:
September 04, 2008
Filing Date:
February 28, 2008
Export Citation:
Assignee:
UNIV HARVARD
CHILDRENS MEDICAL CT CORP
NUCHEM PHARMACEUTICALS INC
CHILDRENS MEDICAL CT CORP
NUCHEM PHARMACEUTICALS INC
International Classes:
C07C25/18; C07D295/14; A61K31/015; A61K31/02; A61K31/025; A61K31/03; A61K31/045; A61K31/05; A61K31/065; A61K31/075; A61K31/085; A61K31/10; A61K31/11; A61K31/12; A61K31/135; A61K31/15; A61K31/165; A61K31/19; A61K31/192; A61K31/195; A61K31/215; A61K31/222; A61K31/275; A61K31/277; A61K31/34; A61K31/381; A61K31/40; A61K31/44; A61K31/4453; A61P7/00; A61P7/06; A61P9/10; A61P17/00; A61P17/02; A61P31/12; A61P35/00; A61P43/00; C07C15/16; C07C17/35; C07C22/04; C07C33/24; C07C33/28; C07C33/34; C07C33/46; C07C39/15; C07C39/367; C07C43/164; C07C43/225; C07C43/23; C07C45/00; C07C45/44; C07C47/23; C07C47/24; C07C47/273; C07C49/163; C07C49/215; C07C49/233; C07C57/38; C07C57/40; C07C57/46; C07C57/58; C07C69/616; C07C69/65; C07C69/76; C07C211/27; C07C211/52; C07C211/54; C07C215/68; C07C229/14; C07C233/11; C07C239/20; C07C239/22; C07C255/33; C07C255/35; C07C259/06; C07C321/10; C07D207/26; C07D213/06; C07D213/16; C07D213/20; C07D213/30; C07D295/145; C07D307/33; C07F7/08; C07F7/10; C07F7/30; C07F9/535
Domestic Patent References:
| JPH0248569A | 1990-02-19 | |||
| JPS5673075A | 1981-06-17 | |||
| JPH10511080A | 1998-10-27 |
Foreign References:
| WO1996008242A2 | 1996-03-21 | |||
| US4851404A | 1989-07-25 | |||
| US2938830A | 1960-05-31 | |||
| GB875955A | 1961-08-23 | |||
| GB897693A | 1962-05-30 | |||
| DE1445722A1 | 1968-12-05 |
Attorney, Agent or Firm:
Kiyoji Kuzuwa