Title:
USE OF ALPHA-AMINOFLUOROKETONE IN PREPARING ACTIVATOR OF CARDIOVASUCULAR SYSTEM AND HYPERTENSION
Document Type and Number:
Japanese Patent JPH02247123
Kind Code:
A
Abstract:
PURPOSE: To obtain a cardiovascularly/anti-hypertensively active agent containing a specific α-aminofluoroketone such as benzoyloxycarbonyl-1- phenylalanylalanylfluoromethyl ketone. CONSTITUTION: This medicinal agent contains a compound of formula I, II, III or IV [R1 and R2 are each H, a (substituted) 1-6C alkyl, aryl or 1-4C alkyl- aryl; (n) is an integer of 1-4; X is a terminal-protecting group ; Y is an amino acid or a peptide containing 2 to 6 amino acids], esp. a compound of formula V, as active ingredient. This agent is useful for preventing or treating cardiovascular disturbances such as congestive heart insufficiency, left ventricular hypertrophy, cerebrovascular stroke like apoplexy. The daily oral dose of this medicinal agent is normally 700 mg to 3.5 g (for the compound of formula V, 700mg to 2.5g) in one to several portions.
Inventors:
ANISU KUSURO MIRU
Application Number:
JP1594890A
Publication Date:
October 02, 1990
Filing Date:
January 25, 1990
Export Citation:
Assignee:
SANDOZ AG
International Classes:
A61K31/195; A61K31/395; A61K31/396; A61K31/397; A61K38/00; A61K38/04; A61P9/12; C07D203/08; C07D205/04; C07D207/08; C07D211/30; (IPC1-7): A61K31/195; A61K31/395; A61K37/02; C07D203/08; C07D205/04; C07D207/08; C07D211/30
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)
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