Title:
USE OF PREGNANE AND ANDROSTANE STEROIDS FOR MANUFACTURE OF PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CNS DISORDERS
Document Type and Number:
Japanese Patent JP2015147774
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide: steroid compounds with increased resistance against metabolism and increased water solubility which act on the γ-aminobutyric acid receptor-chloride ionophore (GABA-R) complex and are used in the treatment of disorders of the central nervous system (CNS); and methods for their manufacture.SOLUTION: The present invention provides methods of the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and methods of prevention, alleviation or treatment of the disorders, by using GABAA receptor modulators, including 3α-ethynyl, 3β-hydroxyl, androstan-17-one oxime or a pharmaceutically acceptable salt or solvate thereof.
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Inventors:
TORBJOERN BAECKSTROEM
RAGAGNIN GIANNA
RAGAGNIN GIANNA
Application Number:
JP2015047791A
Publication Date:
August 20, 2015
Filing Date:
March 11, 2015
Export Citation:
Assignee:
UMECRINE COGNITION AB
International Classes:
C07J1/00; A61K31/568; A61P3/02; A61P3/04; A61P15/00; A61P19/00; A61P25/00; A61P25/02; A61P25/10; A61P25/14; A61P25/20; A61P25/24; A61P25/28; A61P27/02; A61P27/16; A61P37/08; A61P43/00
Domestic Patent References:
| JP2013177411A | 2013-09-09 | |||
| JPH08511771A | 1996-12-10 | |||
| JPH06505958A | 1994-07-07 |
Foreign References:
| FR1463755A | 1966-07-22 |
Attorney, Agent or Firm:
Seiji Ohno
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Reiko Tanaka
Yuko Matsuniya
Ken Kitano