Title:
USE OF SUBLINGUAL DEXMEDETOMIDINE FOR TREATMENT OF AGITATION
Document Type and Number:
Japanese Patent JP2022040229
Kind Code:
A
Abstract:
To provide compositions and the like for treating agitation or signs of agitation.SOLUTION: The invention discloses a method for treating agitation or signs of agitation in a subject, which method comprises sublingually administering an effective amount of an alpha-2 adrenergic agonist, more specifically, dexmedetomidine or a pharmaceutically acceptable salt thereof. The method is especially suitable for treating agitation associated with neurodegenerative and/or neuropsychiatric diseases. Also disclosed is the sublingual administration of an alpha-2 adrenergic agonist, more specifically, dexmedetomidine or a pharmaceutically acceptable salt thereof, at a dose that is effective to treat agitation or the signs of agitation in a subject, but does not cause significant sedation.SELECTED DRAWING: Figure 1A
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Inventors:
KRISHNAN NANDABALAN
FRANK YOCCA
SAMEER SHARMA
FRANK YOCCA
SAMEER SHARMA
Application Number:
JP2022001535A
Publication Date:
March 10, 2022
Filing Date:
January 07, 2022
Export Citation:
Assignee:
BIOXCEL THERAPEUTICS INC
International Classes:
A61K31/4174; A61K9/08; A61K9/12; A61K9/20; A61K47/02; A61K47/12; A61K47/26; A61K47/32; A61K47/38; A61P25/14; A61P25/28
Domestic Patent References:
| JP2020503323A | 2020-01-30 | |||
| JP2012526854A | 2012-11-01 | |||
| JP2015533153A | 2015-11-19 |
Foreign References:
| WO2016061413A1 | 2016-04-21 | |||
| WO2016061554A1 | 2016-04-21 |
Other References:
MINERVA ANESTESIOL, 2014;80:167-175, JPN6020023135, ISSN: 0004986695
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
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