VEGI(VASCULAR ENDOTHELIAL CELL GROWTH INHIBITOR) AS INHIBITOR OF NEOVASCULARIZATION AND TUMOR GROWTH

Title:

VEGI(VASCULAR ENDOTHELIAL CELL GROWTH INHIBITOR) AS INHIBITOR OF NEOVASCULARIZATION AND TUMOR GROWTH

Document Type and Number:

Japanese Patent JP2009165466

Kind Code:

A

Abstract:

To provide a VEGI inhibiting neovascularization in cellular models and tumorigenesis in animal models, and to provide a method for using the same.

An isolated nucleic acid molecule is provided, comprising a polynucleotide selected from the group consisting of (a) a polypeptide comprising amino acids 1 to 174 of a specific amino acid sequence, (b) a polypeptide comprising amino acids 23-174 of a specific amino acid sequence, (c) a polypeptide comprising amino acids 39-174 of a specific amino acid sequence, (d) a polynucleotide encoding fragments having neovascularization-inhibitory activity of the polynucleotide (a), respectively, (e) a polynucleotide hybridizable with the complement of a polypeptide having neovascularization-inhibitory activity, (f) a polynucleotide encoding the allelic form of the polynucleotide (a), and (g) the complementary strand of (a), (b), (c), (d), (e) or (f).

Inventors:

LI LU-YUAN
ZHAI YIFAN
YU GUO-LIANG
NI JIAN
LIPPMAN MARC E
ROSEN CRAIG A

Application Number:

JP2008300188A

Publication Date:

July 30, 2009

Filing Date:

November 25, 2008

Export Citation:

Click for automatic bibliography generation Help

Assignee:

HUMAN GENOME SCIENCES INC
GEORGETOWN UNIV MEDICAL CT

International Classes:

C12N15/09; A61K31/7088; A61K31/711; A61K38/00; A61K48/00; A61P1/00; A61P9/00; A61P9/10; A61P9/14; A61P17/00; A61P17/02; A61P17/06; A61P27/02; A61P27/06; A61P35/00; A61P37/00; A61P37/06; A61P43/00; C07K14/47; C07K14/525; C07K14/705; C12Q1/68; G01N33/53

Attorney, Agent or Firm:

Hidesaku Yamamoto

Previous Patent: METHOD FOR PRODUCING ALCOHOLIC BEVERAGE HAVING FLAVOR OF FERMENTED MALT BEVERAGE

Next Patent: STAPHYLOCOCCUS AUREUS PROTEIN AND NUCLEIC ACID ENCODING THE SAME