Title:
ビタミン-マイトマイシン結合体
Document Type and Number:
Japanese Patent JP4814520
Kind Code:
B2
Abstract:
The invention relates to folate-mitomycin conjugates, to a method of using the conjugates to selectively eliminate a population of pathogenic cells in a host animal harbouring the pathogenic cells, and to a method of preparation of the conjugates. The conjugate is of general formula B-L-X wherein the group B is a folate, or an analog or a derivative thereof, that binds to a surface accessible folate receptor that is uniquely expressed, overexpressed, or preferentially expressed by a population of pathogenic cells, wherein the group L comprises a cleavable linker, and wherein the group X comprises a mitomycin compound, or an analog or a derivative thereof. An additional therapeutic agent, such as a chemotherapeutic agent, can be administered in combination with the conjugate.
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Inventors:
Vrakhov, Iontocho, Radslavov
Lemon, Christopher, Paul
Lemon, Christopher, Paul
Application Number:
JP2004505379A
Publication Date:
November 16, 2011
Filing Date:
May 13, 2003
Export Citation:
Assignee:
End Site, Incorporated
International Classes:
A61K47/48; A61K31/407; A61K45/00; A61P35/00; A61P43/00; C07D475/02; C07D475/04; C07D498/02; C07D519/00; C07H23/00
Domestic Patent References:
| JP2003512338A | 2003-04-02 | |||
| JP2005501052A | 2005-01-13 | |||
| JP2005532252A | 2005-10-27 | |||
| JP2005533026A | 2005-11-04 | |||
| JP2002543111A | 2002-12-17 | |||
| JP2003506319A | 2003-02-18 | |||
| JP2003528924A | 2003-09-30 |
Foreign References:
| WO1988001622A1 | 1988-03-10 | |||
| WO2000074721A1 | 2000-12-14 | |||
| WO2001028592A1 | 2001-04-26 |
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation