Title:
頭頸部がんの検出を補助する方法
Document Type and Number:
Japanese Patent JP7390002
Kind Code:
B2
Abstract:
The present invention aims at providing a method of assisting the detection of head and neck cancer with high accuracy. The present invention provides a method of assisting the detection of head and neck cancer, which includes using as an index the abundance of at least one of miRNAs, isoform miRNAs (isomiRs), precursor miRNAs, transfer RNA fragments (tRFs), or non-coding RNA fragments (LincRNAs or MiscRNAs) contained in a test sample isolated from a living body, whose nucleotide sequence is represented by any one of SEQ ID NOs: 162, 160, 145, 143, 146, 140, 141, 1 to 139, 142, 144, 147 to 159, and 161, wherein a higher abundance of at least one of the miRNAs, isomiRs, precursor miRNAs, transfer RNA fragments, or non-coding RNA fragments whose nucleotide sequence is represented by any one of SEQ ID NOs: 1 to 71 and 118 to 136 than that of healthy subjects or a lower abundance of at least one of the miRNAs, isomiRs, precursor miRNAs, transfer RNA fragments, or non-coding RNA fragments whose nucleotide sequence is represented by any one of SEQ ID NOs: 72 to 117 and 137 to 162 than that of healthy subjects indicates a higher likelihood of having head and neck cancer.
Inventors:
Eitoshi Tahara
Makoto Tahara
Makoto Tahara
Application Number:
JP2019559214A
Publication Date:
December 01, 2023
Filing Date:
December 13, 2018
Export Citation:
Assignee:
Hiroshima University
International Classes:
C12Q1/6886
Domestic Patent References:
| JP2009171876A | ||||
| JP2011072229A |
Foreign References:
| WO2009150839A1 | ||||
| WO2012161124A1 |
Other References:
RABINOWITS G. et al.,Frontiers in Oncology,2017年08月29日,Vol. 7, Article 191,pp.1-5
HUANG Z. et al.,Cancer Medicine,2016年12月30日,Vol. 6, No. 1,pp. 109-119
LANGEVIN S. et al.,Oncotarget,2017年07月27日,Vol. 8, No. 47,pp. 82459-82474
BOLDRUP L. et al.,Oncotarget,2017年09月30日,Vol. 8, No. 61,pp. 103437-103448
MIN A. et al.,BioMed Research International,2015年
LI X. et al.,Oncotarget,2017年10月27日,Vol. 8, No. 6,pp. 10726-10740
Cancer Res,2012年,Vol.72(8_Supplement), No.191
MOLECULAR MEDICINE REPORTS,2015年,Vol.12,885-894
Clin J Clinicians,2014年,Vol.8, No.9,pp.1669-1673
HUANG Z. et al.,Cancer Medicine,2016年12月30日,Vol. 6, No. 1,pp. 109-119
LANGEVIN S. et al.,Oncotarget,2017年07月27日,Vol. 8, No. 47,pp. 82459-82474
BOLDRUP L. et al.,Oncotarget,2017年09月30日,Vol. 8, No. 61,pp. 103437-103448
MIN A. et al.,BioMed Research International,2015年
LI X. et al.,Oncotarget,2017年10月27日,Vol. 8, No. 6,pp. 10726-10740
Cancer Res,2012年,Vol.72(8_Supplement), No.191
MOLECULAR MEDICINE REPORTS,2015年,Vol.12,885-894
Clin J Clinicians,2014年,Vol.8, No.9,pp.1669-1673
Attorney, Agent or Firm:
Patent Attorney Corporation Tanikawa International Patent Office