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Title:
新規の種類のヒストン脱アセチル化酵素阻害剤としてのZn2+キレートモチーフ係留短鎖脂肪酸
Document Type and Number:
Japanese Patent JP5107579
Kind Code:
B2
Abstract:
Zn2+-chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests.

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Inventors:
Chen, Chin-Chi
Cian, Lou
Application Number:
JP2006542704A
Publication Date:
December 26, 2012
Filing Date:
December 01, 2004
Export Citation:
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Assignee:
The Ohio State University Research Foundation
International Classes:
A61K31/167; A61K31/19; A61K31/4402; A61P9/00; A61P17/06; A61P31/00; A61P35/00; A61P43/00; C07C237/20; C07C237/22; C07C237/40; C07C237/42; C07C259/06; C07C259/10; C07D213/81; C12N9/99; A61K
Domestic Patent References:
JP11302173A
JP10152462A
JP63115852A
JP2003137866A
JP2003226680A
JP2003508386A
JP2006509021A
Foreign References:
WO2003013493A1
WO2002026696A1
WO2002022577A1
Other References:
KRAKER, AJ. et al,Molecular Cancer Therapeutics,2003年 4月,Vol.2,p.401-408
KIM,DK. et al,J Med Chem,2003年 1月,Vol.46,p.5745-5751
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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