Title:
がん治療のための方法として低酸素誘導因子−２αを安定化するための、化合物および組成物
Document Type and Number:
Japanese Patent JP2014522410
Kind Code:
A
Abstract:
The invention relates to a composition for use in a method for treating cancer in a subject. The composition comprises the compound {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid or a pharmaceutically acceptable salt thereof. The invention further provides in vitro or ex vivo methods for increasing levels of sVEGF-1 secreted from a cell and for decreasing levels of PGK in a cell comprising administering to the cell an effective amount of {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid. {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid has the formula
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Inventors:
Shal Witz Robert
Gardner Joseph H.
Janusz John M.
Gardner Joseph H.
Janusz John M.
Application Number:
JP2014514563A
Publication Date:
September 04, 2014
Filing Date:
June 05, 2012
Export Citation:
Assignee:
アケビア Therapeutics In condominium lei テッド AKEBIA THERAPEUTICS INC.
International Classes:
C07D213/81; A61K31/337; A61K31/4418; A61K31/4745; A61K31/517; A61K31/704; A61K31/7068; A61K38/00; A61K39/395; A61K45/00; A61P1/00; A61P1/02; A61P1/16; A61P1/18; A61P5/00; A61P11/00; A61P11/02; A61P11/04; A61P13/02; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P19/08; A61P21/00; A61P25/00; A61P27/02; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07C211/63; C07C215/08; C07F1/02; C07F1/04; C07F1/06; C07F1/10
Domestic Patent References:
| JP2009541486A | 2009-11-26 | |||
| JP2010527378A | 2010-08-12 | |||
| JP2005530780A | 2005-10-13 | |||
| JP2006526646A | 2006-11-24 |
Foreign References:
| WO2009020119A1 | 2009-02-12 | |||
| WO2011057112A1 | 2011-05-12 |
Other References:
Ｃ．Ｇ．ＷＥＲＭＵＴＨ編, 「最新 創薬化学 下巻」, vol. ３４７〜３６５頁, JPN6014029314, 25 September 1999 (1999-09-25), ISSN: 0003164062
Attorney, Agent or Firm:
Masahiro Nanjo
Seta Aya child
Inami 興一朗
Seta Aya child
Inami 興一朗