The compound for the improved stem cell specialization to hepatic cells

Title:

The compound for the improved stem cell specialization to hepatic cells

Document Type and Number:

Japanese Patent JP6129360

Kind Code:

B2

Abstract:

The invention relates to the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein R1-R11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are useful in differentiating stem cells into more mature or adult-like hepatocytes for use as drug screening platforms and in disease modeling applications.

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Inventors:

Eric, Chao
Hamilton, Matthew Michael
Cameoka
Leonard, brian
Triyatni, Miriam

Application Number:

JP2015562101A

Publication Date:

May 17, 2017

Filing Date:

March 12, 2014

Export Citation:

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Assignee:

F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT

International Classes:

C07D401/04; A61K31/4439; A61P1/16; A61P31/20; C12N5/10; C12Q1/02; C12Q1/68

Domestic Patent References:

JP2009256369A

Foreign References:

WO2012141038A1

Attorney, Agent or Firm:

Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Akiko Nakahama

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