Title:
A compound which has the high prevention activity to protein kinases G, and a manufacturing method for the same
Document Type and Number:
Japanese Patent JP6195100
Kind Code:
B2
Abstract:
Disclosed are a compound of Formula I having higher inhibition of protein kinase G (PKG) activity and pharmaceutically acceptable salts thereof. In Formula I, R 1 and R 2 are the same or different, each being independently chosen from the halogens, the C 1 -C 6 alkoxyl group, the C 1 -C 6 alkyl group, the C 2 -C 6 alkenyl group, and the C 2 -C 6 alkynyl group; R 3 is chosen from H, the halogens, the substituted or unsubstituted C 1 -C 6 alkyl group, C 3 -C 6 cycloalkyl group, C 2 -C 6 alkenyl group, and C 2 -C 6 alkynyl group, aryl group, and heteroaryl group; and n is an integer between 0 and 15. Also disclosed is a pharmaceutical composition comprising said compound, the use of the compound in treating pains, in particular chronic pain, a preparation method for the compound, and a new intermediate.
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Inventors:
Fen, Zewan
Jiao, Xuan
Wang, Cheng Guo
Ryu, Yang
Jiao, Xuan
Wang, Cheng Guo
Ryu, Yang
Application Number:
JP2016550929A
Publication Date:
September 13, 2017
Filing Date:
November 04, 2014
Export Citation:
Assignee:
Jenchem Technology Company, Limited (Tianjin)
International Classes:
C07D403/12; A61K31/416; A61K31/77; A61K47/54; A61K47/60; A61P25/04; A61P43/00; C07C65/40; C07C69/76; C07D207/14
Domestic Patent References:
| JP7224030A |
Foreign References:
| WO2007095586A2 | ||||
| CN1283643A | ||||
| WO2012079017A1 |
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Kazuhiro Yamaguchi
Junichiro Sakamaki
Masakazu Noda
Kazuhiro Yamaguchi
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