多能性幹細胞からの血液細胞分化に関する培養方法 - National University Corporation University of Tokyo

Title:

多能性幹細胞からの血液細胞分化に関する培養方法

Document Type and Number:

Japanese Patent JP5597904

Kind Code:

B2

Abstract:

It is an object of the present invention to provide a method for efficient differentiation into blood cells. Specifically, in the present invention, when blood cells are produced from pluripotent stem cells such as ES cells or iPS cells in vitro, the cells are cultured under a low oxygen partial pressure to increase the efficiency of differentiating the pluripotent stem cells into hematopoietic progenitor cells, erythroid progenitor cells, and the like, so as to increase the number of finally obtained, desired blood cells.

More Like This:

WO/2022/089606	METHODS FOR PREPARING MATURE RED BLOOD CELLS IN VITRO
WO/2019/086476	METHODS FOR DETERMINING SELECTIVITY OF TEST COMPOUNDS
JP6864287	Cytoplasm exchange method, cell production method, and equipment

Inventors:

Sano 進弥
Hiroyuki Eto
Naoya Takayama
Hiromitsu Nakauchi

Application Number:

JP2012533036A

Publication Date:

October 01, 2014

Filing Date:

September 09, 2011

Export Citation:

Click for automatic bibliography generation Help

Assignee:

National University Corporation University of Tokyo
TERUMO CORP.

International Classes:

C12N5/078; A61K35/12; A61K35/14; A61K35/18; A61P7/00; A61P7/08; C12N5/0789; C12N5/10; C12Q1/06; C12Q1/68; C12N15/09

Foreign References:

WO2008041370A1	2008-04-10
WO2009122747A1	2009-10-08
WO2010096746A1	2010-08-26

Other References:

JPN6014017627; ＭＡ，Ｆ　ｅｔ　ａｌ．: 'Ｇｅｎｅｒａｔｉｏｎ　ｏｆ　ｆｕｎｃｔｉｏｎａｌ　ｅｒｙｔｈｒｏｃｙｔｅｓ　ｆｒｏｍ　ｈｕｍａｎ　ｅｍｂｒｙｏｎｉｃ　ｓｔｅｍ　ｃｅｌｌ-ｄｅｒｉｖｅｄ　ｄｅｆｉｎｉｔｉｖｅ　ｈｅｍａｔｏｐｏｉｅｓｉ' ＰＮＡＳｖｏｌ．１０５（３５）, 20080902, ｐｐ．１３０８７-１３０９２
JPN6014017629; ＴＡＫＡＹＡＭＡ，Ｎ　ｅｔ　ａｌ．: 'Ｇｅｎｅｒａｔｉｏｎ　ｏｆ　ｆｕｎｃｔｉｏｎａｌ　ｐｌａｔｅｌｅｔｓ　ｆｒｏｍ　ｈｕｍａｎ　ｅｍｂｒｙｏｎｉｃ　ｓｔｅｍ　ｃｅｌｌｓ　ｉｎ　ｖｉｔｒｏ　ｖｉａ　ＥＳ-ｓａｃｓ，　ＶＥＧＦ-ｐｒｏｍｏｔ' Ｂｌｏｏｄｖｏｌ．１１１（１１）, 20080601, ｐｐ．５２９８-５３０６

Attorney, Agent or Firm:

Yasushi Okuhara

Previous Patent: 金含有物への糖鎖の導入法

Next Patent: SPECIALLFORM COLLECTING MATERIAL