Title:
徐放性マイクロスフェアの混合剤型を連続単一工程で製造する方法
Document Type and Number:
Japanese Patent JP4072830
Kind Code:
B2
Abstract:
Disclosed is a method for preparing a mixed formulation of sustained release microspheres with various compositions by a continuous one-step process. The present method is characterized by preparing the mixed formulation of sustained release microspheres with different compositions by a continuous one-step process by continuously introducing the mixed fluids into a dryer from the two or more different fluids for preparation of sustained release microspheres containing a biodegradable polymer, a drug, an additive and a solvent with different types of contents or both of the components, by controlling the mixing ratios of the fluids according to the time, unlike a conventional method including spray-drying a mixture of microspheres containing a biodegradable polymer, a drug, an additive and a solvent with a single composition. The present method can achieve a desired drug release, which is difficult to be obtained by conventional microspheres with a single composition, by preparing microspheres by a continuous one-step process, and can simplify the conventional complex process of separately preparing several microsphere formulations and then mixing the formulations at a proper ratio to achieve a desired drug release.
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Inventors:
Lee, Hee Young
Kim, sunkyu
Kim, Jun So
Lee, Disk
Jun, Yong Hwan
Kim, jun inn
Yeo Mi
Chan, Seung
Park, Keedon
Choi, Wheel
Kim, sunkyu
Kim, Jun So
Lee, Disk
Jun, Yong Hwan
Kim, jun inn
Yeo Mi
Chan, Seung
Park, Keedon
Choi, Wheel
Application Number:
JP2004187870A
Publication Date:
April 09, 2008
Filing Date:
June 25, 2004
Export Citation:
Assignee:
Peptron Seeo., LDT
International Classes:
A61K9/50; A61K38/00; A61K9/16; A61K9/52; A61K9/62; A61K38/22; A61K38/24; A61K47/12; A61K47/34; A61K47/42; A61K47/44
Domestic Patent References:
| JP632930A | ||||
| JP4506931A | ||||
| JP5500961A | ||||
| JP7507768A |
Other References:
Johansen P. et al.,Technological considerations related to the up-scaling of protein microencapsulation by spray-drying.,European Journal of Pharmaceutics and Biopharmaceutics,2000年,Vol.50,p.413-417
Elisabetta E. et al.,Production of eudragit microparticles by spray-drying technique: Influence of experimental parameters on morphological and dimensional characteristics.,Pharmaceutical Development and Technology,2000年,Vol.5, No.2,p.267-278
Elisabetta E. et al.,Production of eudragit microparticles by spray-drying technique: Influence of experimental parameters on morphological and dimensional characteristics.,Pharmaceutical Development and Technology,2000年,Vol.5, No.2,p.267-278
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Furudate Kutanko
Yuriko Shinobu
Furudate Kutanko