Title:
グルココルチコイド関連機能不全に関連した精神病の処置のための方法。
Document Type and Number:
Japanese Patent JP5180125
Kind Code:
B2
Abstract:
This invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for amelirating psychotic major depression. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods.
Inventors:
Alan F. Schatsburg
Joseph Kay. Bellanov
Joseph Kay. Bellanov
Application Number:
JP2009071039A
Publication Date:
April 10, 2013
Filing Date:
March 23, 2009
Export Citation:
Assignee:
Board of Trustees of the Leland Stanford Junior University
International Classes:
A61K31/575; A61K45/00; A61K31/00; A61K31/569; A61K31/57; A61P25/18; A61P25/24; A61P25/30; A61P43/00; C07J1/00
Other References:
Murphy,B.E.P. et al.,Possible use of glucocorticoid receptor antagonists in the treatment of major depression: Preliminar,J. Psychiatry Neurosci.,1993年11月 1日,Vol.18,No.5,P.209-213
Bocquel,M.T. et al.,Type II antagonists impair the DNA binding of steroid hormone receptors without affecting dimerization,J. Steroid Biochem. Mol. Biol.,1993年 4月 1日,Vol.45,No.4,P.205-215
Schust,D.J. et al.,Progesterone-induced immunosuppression is not mediated through the progesterone receptor,Hum. Reprod.,1996年 5月,Vol.11,No.5,P.980-985
Bocquel,M.T. et al.,Type II antagonists impair the DNA binding of steroid hormone receptors without affecting dimerization,J. Steroid Biochem. Mol. Biol.,1993年 4月 1日,Vol.45,No.4,P.205-215
Schust,D.J. et al.,Progesterone-induced immunosuppression is not mediated through the progesterone receptor,Hum. Reprod.,1996年 5月,Vol.11,No.5,P.980-985
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita