Title:
Genetically modified mice expressing chimeric major histocompatibility complex (MHC) II molecules
Document Type and Number:
Japanese Patent JP6285361
Kind Code:
B2
Abstract:
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
Inventors:
McDonald's, Lynn
Murphy, Andrew Jay.
Two, Nakshin
Regular, cagan
Bora Nina, Bella
Stevens, Sean
Murphy, Andrew Jay.
Two, Nakshin
Regular, cagan
Bora Nina, Bella
Stevens, Sean
Application Number:
JP2014539027A
Publication Date:
February 28, 2018
Filing Date:
October 26, 2012
Export Citation:
Assignee:
REGENERON PHARMACEUTICALS, INC.
International Classes:
A01K67/027; C07K14/74; C07K19/00; C12N5/10; C12N15/09
Domestic Patent References:
| JP2008500014A |
Foreign References:
| US20070209083 |
Other References:
J. Exp. Med.,1996年,Vol.183,pp.2635-2644
Proc. Natl. Acad. Sci. USA,1994年,Vol.91,pp.6151-6155
J. Exp. Med.,1995年,Vol.181,pp.867-875
Proc. Natl. Acad. Sci. USA,1994年,Vol.91,pp.6151-6155
J. Exp. Med.,1995年,Vol.181,pp.867-875
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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