グルカゴン受容体の新規アンタゴニスト

Title:

グルカゴン受容体の新規アンタゴニスト

Document Type and Number:

Japanese Patent JP6377589

Kind Code:

B2

Abstract:

The present invention provides for novel compounds of Formula I and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as their use in methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistence and hyperglycemia.

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Inventors:

George E Gomez-Galeno
Raja Kay Lady
Paul Day Fan Plouhe
Robert Huerta Remus
Tan Fu Nguyen
Matthew P. Grote
Khun Dan
Scott Jay Hecker
Benkat Lady Mali
Chen Min Wei
Jiri Seung
Serge Henri Boyer
Re-Haitin
William Craigo

Application Number:

JP2015196171A

Publication Date:

August 22, 2018

Filing Date:

October 01, 2015

Export Citation:

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Assignee:

Ligand Pharmaceuticals, Inc.

International Classes:

C07C309/15; A61K31/185; A61K31/277; A61K31/341; A61K31/343; A61K31/353; A61K31/36; A61K31/381; A61K31/4025; A61K31/4045; A61K31/4155; A61K31/4184; A61K31/42; A61K31/423; A61K31/428; A61K31/437; A61K31/4418; A61K31/443; A61K31/495; A61K31/5375; A61P3/10; A61P5/50; A61P43/00; C07D209/14; C07D213/40; C07D213/75; C07D235/18; C07D235/30; C07D261/08; C07D261/20; C07D263/57; C07D277/66; C07D295/135; C07D295/185; C07D307/68; C07D307/81; C07D311/70; C07D317/66; C07D333/38; C07D333/58; C07D405/04; C07D405/12; C07D407/12; C07D409/12; C07D413/04; C07D413/10; C07D413/12; C07D471/04; C07D498/04

Domestic Patent References:

JP5322951B2
JP2013177426A
JP2005511683A
JP2002544254A
JP2006500325A

Other References:

KURUKULASURIYA,R. et al.,Biaryl amide glucagon receptor antagonists,Bioorganic & Medicinal Chemistry Letters,2004年,Vol.14, No.9,p.2047-2050

Attorney, Agent or Firm:

Samejima Mutsumi
Nagatoshi Shinagawa
Kure Hidenori
Kamahira Futami
Mizuhara Masahiro

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