Title:
【発明の名称】卵巣特異的遺伝子およびタンパク質
Document Type and Number:
Japanese Patent JP2003512010
Kind Code:
A
Abstract:
Ovary specific proteins O1 180, O1 184 and O1 236, polynucleotides encoding them, antibodies which are immunoreactive with them and vectors and host cells containing O1 180, O1 184 or O1 236 are provided. Also provided are methods for detecting cell proliferative or degenerative disorders of ovarian origin and which are associated with O1 180, O1 184 or O1 236. Further provided are methods for the evaluation of potential contraceptives using the proteins of the invention, as well as methods for the screening for genetic mutations in signaling pathways that are associated with some forms of human infertility or gynecological cancers, also using the proteins/mRNAs/genes of the invention. The proteins/mRNAs/genes of the invention may also be used as markers for identifying primary and metastatic neoplasms of ovarian origin and as indicators of developmental anomalies in prenatal screening procedures. Furthermore, assays of the proteins/mRNAs/genes of the invention can be used in diagnostic assays for detecting forms of infertility and other diseases, including germ cell tumors and polycystic ovary syndrome. The proteins of the invention may be useful targets for in vitro fertilization procedures or in enhancing the number of eggs that can be retrieved from the human donor, e.g., in enhancing the success rate.
More Like This:
| WO/2024/044691 | MODIFIED AAV VECTORS FOR GENE THERAPY |
| WO/2018/164883 | DNA-TEMPLATED MICELLE AND USES THEREOF |
| WO/2000/057185 | METHOD FOR DETECTING SUPERANTIGEN ACTIVITY IN A BIOLOGICAL SAMPLE |
Inventors:
Matez Martin M
Wang Pay
Wang Pay
Application Number:
JP2000578325A
Publication Date:
April 02, 2003
Filing Date:
October 28, 1999
Export Citation:
Assignee:
BAYLOR COLLEGE OF MEDICINE
International Classes:
A61K31/711; A61K35/76; A61K38/00; A61K48/00; A61P5/24; A61P15/00; A61P35/00; A61P43/00; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; G01N33/15; G01N33/53; G01N33/566; G01N33/50; (IPC1-7): C12N15/09; A61K31/711; A61K35/76; A61K38/00; A61K48/00; A61P5/24; A61P15/00; A61P35/00; A61P43/00; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Takao Suzuki (4 others)