The protoberberine biological alkaloid derivative which controls chronic ulcerative colitis, and its use

Japanese Patent JP6162133

B2

Disclosed are derivatives of protoberberine biological alkaloids or physiologically acceptable salts thereof produced by means of a derivative reaction of a source material of biological alkaline quaternary ammonium salts of protoberberine alkaloids, a preparation method for same and pharmaceutical uses thereof. The derivatives of protoberberine biological alkaloids or the physiologically acceptable salts thereof show activity inhibiting ulcerative colitis and can be used in the preparation of drugs for same.

Chin, Hyrin
Wang, Wen
Zhang, Zhuhui
Wu, Lianchi
Don, Anjun
You, Jin Jai
Lee, Ji Hong

JP2014537477A

July 12, 2017

October 24, 2012

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Institute of Materia Medica, Chinese Academy of Medical Sciences

C07D455/03; A61K31/4375; A61P1/04

JP2007223971A
JP2010504919A
JP50024297A

CN1589793A

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Takeshi Ebe
Inoue Akifumi
Kazuo Asahi

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