1-GALACTOSE DERIVATIVES - SYNSORB BIOTECH INC

Title:

1-GALACTOSE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO1999058540

Kind Code:

A3

Abstract:

Disclosed are novel 1-galactose derivatives of formula (I) having a carbon- or nitrogen-containing aglycon linkage. The disclosed compounds inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. The disclosed compounds also inhibit binding of enterovirulent organisms (e.g., bacteria, virus, fungi, and the like), such as Vibrio cholerae and enterotoxigenic strains of Escherichia coli, to their cell surface receptors.

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Inventors:

HINDSGAUL OLE (CA)

Application Number:

PCT/CA1999/000399

Publication Date:

January 13, 2000

Filing Date:

April 29, 1999

Export Citation:

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Assignee:

SYNSORB BIOTECH INC (CA)
HINDSGAUL OLE (CA)

International Classes:

C07H7/02; A61K31/351; A61K31/70; A61K31/7004; A61K31/7008; A61P1/00; A61P1/06; A61P1/12; A61P31/04; C07D309/10; C07H7/04; C07H15/20; C07H15/26; (IPC1-7): C07H15/26; A61K31/70; C07H15/20

Domestic Patent References:

WO1996039189A1	1996-12-12
WO1996039190A1	1996-12-12
WO1996039191A1	1996-12-12
WO1998021222A2	1998-05-22
WO1998021220A2	1998-05-22
WO1998021221A2	1998-05-22

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