Title:
Vκ4-1-IGLC POLYPEPTIDE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/217020
Kind Code:
A1
Abstract:
Disclosed in the present invention are an immunoglobulin κ-type light chain (Vκ4-1-IgLC) polypeptide having a unique Vκ4-1 and the use thereof. The amino acid sequence of the Vκ4-1-IgLC polypeptide is as shown in SEQ ID NO.1, and the polypeptide can be used as a target or a marker for preparing a drug for diagnosing and/or treating tumors or inflammatory diseases, and can also be used for preparing an Integrin-FAK signal pathway inhibitor. An antibody prepared by using the polypeptide as an antigen can effectively inhibit the development of tumors, and provides a new thought for clinical diagnosis and treatment of tumors.
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Inventors:
QIU XIAOYAN (CN)
WANG QIANQIAN (CN)
JIANG WENHUA (CN)
HE ZHIQIAO (CN)
WANG QIANQIAN (CN)
JIANG WENHUA (CN)
HE ZHIQIAO (CN)
Application Number:
PCT/CN2023/092458
Publication Date:
November 16, 2023
Filing Date:
May 06, 2023
Export Citation:
Assignee:
BEIJING AISAIJI BIOPHARMACEUTICAL TECH CO LTD (CN)
International Classes:
A61K39/395; C07K16/00; A61K45/00; A61P1/00; A61P13/12; A61P19/02; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P37/02; C07K16/42
Foreign References:
| CN114920830A | 2022-08-19 |
Other References:
叶青 (YE, QING): "非B细胞来源IgκV区保守序列特异性抗体的制备及鉴定 (Preparation and Characterization of Antibodies Specific to Conservative Sequence of IgκV Region from Non-B Cell)", 中国优秀硕士学位论文全文数据库医药卫生科技辑 (MEDICINE AND HEALTH SCIENCES, CHINESE MASTER’S THESES FULL-TEXT DATABASE), no. 6, 16 June 2009 (2009-06-16)
杨沙 (YANG, SHA): "非B细胞来源Igκ保守序列特异性抗体应用的初步研究与ECDI交联的人脾淋巴细胞诱导供者特异性耐受实验体系的初步建立 (Preliminary Application of Antibodies Against Conservative Sequence of Igκ Derived from Non-B Cell and the Initial Establishment of System for the Induction of Donor Specific Tolerance by ECDI-SPs)", 中国优秀硕士学位论文全文数据库医药卫生科技辑 (MEDICINE AND HEALTH SCIENCES, CHINESE MASTER’S THESES FULL-TEXT DATABASE), no. 2, 15 February 2017 (2017-02-15)
张志丽 (ZHANG, ZHILI): "非B细胞来源Igκ保守序列特异性抗体应用的初步研究 (Non-official translation: Igκ Light Chain Derived from Non-B Cell Participating in Tumor Growth and Metastasis as Novel Extracellular Matrix Protein)", 中国优秀硕士学位论文全文数据库医药卫生科技辑 (MEDICINE AND HEALTH SCIENCES, CHINESE MASTER’S THESES FULL-TEXT DATABASE), no. 8, 15 August 2015 (2015-08-15)
BOTAI LI;LILI ZHU;ZHIGANG ZHANG: "METTL3 Suppresses Pancreatic Ductal Adenocarcinoma Progression through Activating Endogenous dsRNA-induced Anti-Tumor Immunity", ACADEMIC REPORT OF 14TH ANNUAL MEETING OF CHINESE SOCIETY FOR IMMUNOLOGY, CHINESE SOCIETY FOR IMMUNOLOGY, CN, 21 October 2021 (2021-10-21) - 24 October 2021 (2021-10-24), CN, XP009550256
杨沙 (YANG, SHA): "非B细胞来源Igκ保守序列特异性抗体应用的初步研究与ECDI交联的人脾淋巴细胞诱导供者特异性耐受实验体系的初步建立 (Preliminary Application of Antibodies Against Conservative Sequence of Igκ Derived from Non-B Cell and the Initial Establishment of System for the Induction of Donor Specific Tolerance by ECDI-SPs)", 中国优秀硕士学位论文全文数据库医药卫生科技辑 (MEDICINE AND HEALTH SCIENCES, CHINESE MASTER’S THESES FULL-TEXT DATABASE), no. 2, 15 February 2017 (2017-02-15)
张志丽 (ZHANG, ZHILI): "非B细胞来源Igκ保守序列特异性抗体应用的初步研究 (Non-official translation: Igκ Light Chain Derived from Non-B Cell Participating in Tumor Growth and Metastasis as Novel Extracellular Matrix Protein)", 中国优秀硕士学位论文全文数据库医药卫生科技辑 (MEDICINE AND HEALTH SCIENCES, CHINESE MASTER’S THESES FULL-TEXT DATABASE), no. 8, 15 August 2015 (2015-08-15)
BOTAI LI;LILI ZHU;ZHIGANG ZHANG: "METTL3 Suppresses Pancreatic Ductal Adenocarcinoma Progression through Activating Endogenous dsRNA-induced Anti-Tumor Immunity", ACADEMIC REPORT OF 14TH ANNUAL MEETING OF CHINESE SOCIETY FOR IMMUNOLOGY, CHINESE SOCIETY FOR IMMUNOLOGY, CN, 21 October 2021 (2021-10-21) - 24 October 2021 (2021-10-24), CN, XP009550256
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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