Title:
10,10-DIALKYL PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE
Document Type and Number:
WIPO Patent Application WO2004071428
Kind Code:
A3
Abstract:
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula (I); wherein the dashed line indicates the presence or absence of a bond, the hatched wedge indicates the alpha (down) configuration, and the solid triangle indicates the beta (up) configuration; B is a single, double, or triple covalent bond; n is 0-6; X is CH2, S or O; Y is any pharmaceutically acceptable salt of C02H, or C02R, CONR2, CONHCH2CH20H, CON(CH2CH2OH)2,CH2OR, P(O)(OR)2, CONRSO2R, SONR2, or formula (Ia) R is H, C1-6 alkyl or C2-6 alkenyl; R<2> and R<3> are C1-6 linear alkyl which may be the same or different, and may be bonded to each other such that they form a ring incorporating the carbon to which they are commonly attached.
Inventors:
DONDE YARIV (US)
NGUYEN JEREMIAH H (US)
NGUYEN JEREMIAH H (US)
Application Number:
PCT/US2004/003433
Publication Date:
November 10, 2005
Filing Date:
February 06, 2004
Export Citation:
Assignee:
ALLERGAN INC (US)
DONDE YARIV (US)
NGUYEN JEREMIAH H (US)
DONDE YARIV (US)
NGUYEN JEREMIAH H (US)
International Classes:
A61K31/5575; C07C405/00; C07D333/56; C07D333/62; C07D409/08; (IPC1-7): A61K31/557; A61P27/06; C07C177/00
Foreign References:
| US4117014A | 1978-09-26 |
Other References:
PERNET, ANDRE G. ET AL: "Prostaglandin analogs modified at the 10 and 11 positions", TETRAHEDRON LETTERS , (41), 3933-6 CODEN: TELEAY; ISSN: 0040-4039, 1979, XP000957065
PLANTEMA, OTTO G. ET AL: "Synthesis of (.+-.)-10,10-dimethylprostaglandin E1 methyl ester and its 15-epimer", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY (1972-1999) , (3), 304-8 CODEN: JCPRB4; ISSN: 0300-922X, 1978, XP000955879
PLANTEMA, O. G. ET AL: "Synthesis of 10,10-dimethylprostaglandin E1", TETRAHEDRON LETTERS , (51), 4595-8 CODEN: TELEAY; ISSN: 0040-4039, 1975, XP000957113
HAMON A ET AL: "SYNTHESIS OF (+-)- AND 15-EPI(+-)-10,10-DIMETHYLPROSTAGLANDIN E1", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, no. 3, January 1976 (1976-01-01), pages 211 - 214, XP000957115, ISSN: 0040-4039
PATENT ABSTRACTS OF JAPAN vol. 0122, no. 02 (C - 503) 10 June 1988 (1988-06-10)
PATENT ABSTRACTS OF JAPAN vol. 0082, no. 18 (C - 245) 4 October 1984 (1984-10-04)
PLANTEMA, OTTO G. ET AL: "Synthesis of (.+-.)-10,10-dimethylprostaglandin E1 methyl ester and its 15-epimer", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY (1972-1999) , (3), 304-8 CODEN: JCPRB4; ISSN: 0300-922X, 1978, XP000955879
PLANTEMA, O. G. ET AL: "Synthesis of 10,10-dimethylprostaglandin E1", TETRAHEDRON LETTERS , (51), 4595-8 CODEN: TELEAY; ISSN: 0040-4039, 1975, XP000957113
HAMON A ET AL: "SYNTHESIS OF (+-)- AND 15-EPI(+-)-10,10-DIMETHYLPROSTAGLANDIN E1", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, no. 3, January 1976 (1976-01-01), pages 211 - 214, XP000957115, ISSN: 0040-4039
PATENT ABSTRACTS OF JAPAN vol. 0122, no. 02 (C - 503) 10 June 1988 (1988-06-10)
PATENT ABSTRACTS OF JAPAN vol. 0082, no. 18 (C - 245) 4 October 1984 (1984-10-04)
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