Title:
1,3,4-OXADIAZOL-2-ONES AS PPAR DELTA
Document Type and Number:
WIPO Patent Application WO2005097763
Kind Code:
A3
Abstract:
The present invention is directed to 1, 3, 4-oxadiazalones, and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. The compounds of this invention are modulators of PPARdelta and therefore useful as pharmaceutical agents, especially for the treatment of demyelinating diseases and disorders of fatty acid metabolism and glucose utilization.
Inventors:
MCGARRY DANIEL G (US)
GOERLITZER JOCHEN (DE)
KEIL STEFANIE (DE)
CHANDROSS KAREN (US)
MERRILL JEAN (US)
WENDLER WOLFGANG (DE)
GOERLITZER JOCHEN (DE)
KEIL STEFANIE (DE)
CHANDROSS KAREN (US)
MERRILL JEAN (US)
WENDLER WOLFGANG (DE)
Application Number:
PCT/US2005/010855
Publication Date:
December 15, 2005
Filing Date:
March 30, 2005
Export Citation:
Assignee:
AVENTIS PHARMA INC (US)
MCGARRY DANIEL G (US)
GOERLITZER JOCHEN (DE)
KEIL STEFANIE (DE)
CHANDROSS KAREN (US)
MERRILL JEAN (US)
WENDLER WOLFGANG (DE)
MCGARRY DANIEL G (US)
GOERLITZER JOCHEN (DE)
KEIL STEFANIE (DE)
CHANDROSS KAREN (US)
MERRILL JEAN (US)
WENDLER WOLFGANG (DE)
International Classes:
A61K31/4245; C07D413/12; C07D417/12; (IPC1-7): C07D417/12; C07D413/12; A61K31/4245; A61P3/10; A61P3/06
Domestic Patent References:
| WO2000078313A1 | 2000-12-28 | |||
| WO2001000603A1 | 2001-01-04 | |||
| WO2001017994A1 | 2001-03-15 |
Other References:
S. S. KULKARNI ET AL.: "Three-Dimensional Quantitative Structure Activity Relationship (3-D-QSAR) of Antihyperglycemic Agents", BIOORG. MED. CHEM., vol. 7, 1999, pages 1475 - 1485, XP002345584
B. R. HENKE ET AL.: "N-(2-Benzoylphenyl)-L-tyrosine PPAR.gamma. Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents", J. MED. CHEM., vol. 41, no. 25, 11 November 1998 (1998-11-11), pages 5020 - 5036, XP000864731
B. R. HENKE ET AL.: "N-(2-Benzoylphenyl)-L-tyrosine PPAR.gamma. Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents", J. MED. CHEM., vol. 41, no. 25, 11 November 1998 (1998-11-11), pages 5020 - 5036, XP000864731
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