1,4-DIHYDROPYRIDINE DERIVATIVES - NIKKEN CHEMICALS CO LTD

Title:

1,4-DIHYDROPYRIDINE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1999/041250

Kind Code:

A1

Abstract:

1,4-Dihydropyridine derivatives represented by general formula (I) and antagonists against tolerance to anticancer drugs or anticancer drug potentiators containing as the active ingredient these derivatives, pharmacologically acceptable salts thereof or hydrates of the same: wherein R¿1? represents optionally substituted phenyl or pyridyl; R¿2? represents lower C¿1-5? alkyl; R¿3? represents optionally substituted lower C¿1-8? alkyl, alkenyl or alkynyl or optionally substituted lower C¿3-7? cycloalkyl or cycloalkenyl; and R¿4? represents -A-R¿5? (wherein A represents C¿3-5? alkynylene having a triple bond and R¿5? represents optinally substituted pyridyl, quinolyl, isoquinolyl or pyrimidyl).

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Inventors:

TASAKA SHIGEYUKI (JP)
KIUE AKIRA (JP)
OMORI HIROMASA (JP)
TANABE HIROKAZU (JP)
GOMI NORIAKI (JP)

Application Number:

PCT/JP1999/000458

Publication Date:

August 19, 1999

Filing Date:

February 03, 1999

Export Citation:

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Assignee:

NIKKEN CHEMICALS CO LTD (JP)
TASAKA SHIGEYUKI (JP)
KIUE AKIRA (JP)
OMORI HIROMASA (JP)
TANABE HIROKAZU (JP)
GOMI NORIAKI (JP)

International Classes:

C07D401/12; C07D401/14; C07D409/14; C07D471/04; C07D521/00; (IPC1-7): C07D401/12; C07D401/14; C07D409/14; C07D471/04; A61K31/445; A61K31/495; A61K31/505; A61K31/535

Foreign References:

JPS60120861A	1985-06-28
JPS61140567A	1986-06-27
JPH10204061A	1998-08-04

Other References: