2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME

Title:

2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME

Document Type and Number:

WIPO Patent Application WO/2015/199205

Kind Code:

A1

Abstract:

Provided is a compound represented by general formula (1) or a salt thereof, and a medicine containing the compound or the salt. (In the formula, R1 represents a hydrogen atom or CO2Ra; R2 represents a hydrogen atom, a halogen atom, or CO2Ra; R3 represents a hydrogen atom or a C1–10 hydroxyalkyl group; R4 represents a hydrogen atom, a hydroxy group, or a C1–10 alkoxy group; R5 represents a C1–5 chain alkyl group in which the hydrogen atoms are optionally substituted with halogen atoms, a C3–5 cyclic alkyl group in which the hydrogen atoms are optionally substituted with halogen atoms, a C1–5 hydroxyalkyl group, or an o-, p-, or m-halobenzyl group; A represents CH or a nitrogen atom; X1 and X3 independently represent hydrogen atoms or halogen atoms; X2 represents a hydrogen atom, a halogen atom, or a nitrile group; at least one of X1, X2, and X3 represents a halogen atom; and Ra independently represents a C1–10 alkyl group.)

Inventors:

IZAWA AKIHIRO (JP)
AKAMA KEI (JP)
OKUMURA YUKI (JP)
FUKUI YURIE (JP)
KOBASHI NOBUYA (JP)
ABE TSUTOMU (JP)
DOI YOSHIHIRO (JP)
IKENAGA MIHO (JP)
SAJI HIDEO (JP)
KIMURA HIROYUKI (JP)
NARUSE MITSUHIDE (JP)

Application Number:

PCT/JP2015/068431

Publication Date:

December 30, 2015

Filing Date:

June 25, 2015

Export Citation:

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Assignee:

NIHON MEDIPHYSICS CO LTD (JP)
UNIV KYOTO (JP)
NAT HOSPITAL ORGANIZATION (JP)

International Classes:

C07D401/14; A61K31/4439; A61K51/00; A61P35/00

Domestic Patent References:

WO2012012478A1

2012-01-26

Foreign References:

JP2009539822A	2009-11-19
JP2013534911A	2013-09-09
JP2015110563A	2015-06-18

Other References: