Title:
SIX-MEMBERED RING DERIVATIVE HAVING TRPV4 INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2015/199206
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by formula (I), a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the compound or the salt.
(In the formula, R1 represents a hydrogen atom or the like; -X- represents -S- or the like; =Y- represents =C(R3)- or the like; R3 represents a hydrogen atom or the like; A represents a substituted or unsubstituted aromatic carbocyclic group, a substituted or unsubstituted aromatic heterocyclic group or the like; ring B represents a substituted or unsubstituted aromatic heterocyclic ring, a substituted or unsubstituted non-aromatic carbocyclic ring or the like; ring D represents a substituted or unsubstituted piperazine, a substituted or unsubstituted piperidine, a substituted or unsubstituted morpholine or the like; and ring E represents a substituted or unsubstituted aromatic heterocyclic ring, a substituted or unsubstituted aromatic carbocyclic ring or the like.)
Inventors:
KUDO HIROMI (JP)
YAMAGUCHI HIROKI (JP)
YUKIMASA AKIRA (JP)
OGAWA TOMOYUKI (JP)
TSUNO NAOKI (JP)
YAMAGUCHI HIROKI (JP)
YUKIMASA AKIRA (JP)
OGAWA TOMOYUKI (JP)
TSUNO NAOKI (JP)
Application Number:
PCT/JP2015/068448
Publication Date:
December 30, 2015
Filing Date:
June 26, 2015
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D417/14; A61K31/4545; A61K31/46; A61K31/496; A61K31/497; A61K31/4995; A61K31/501; A61K31/506; A61K31/5377; A61K31/5386; A61P1/04; A61P3/04; A61P3/10; A61P9/00; A61P11/06; A61P13/10; A61P17/00; A61P19/10; A61P25/04; A61P27/02; A61P29/00; A61P35/04; A61P37/08; A61P43/00; C07D451/02; C07D487/08; C07D498/08
Domestic Patent References:
| WO2015046193A1 | 2015-04-02 | |||
| WO2012122391A1 | 2012-09-13 | |||
| WO2013146754A1 | 2013-10-03 | |||
| WO2012144661A1 | 2012-10-26 | |||
| WO2012037351A1 | 2012-03-22 | |||
| WO2003004467A2 | 2003-01-16 |
Other References:
DATABASE REGISTRY [o] 25 January 2008 (2008-01-25), retrieved from STN Database accession no. 1030668- 07-5
FABIEN VINCENT ET AL.: "TRPV4 Agonists and Antagonists", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 11, no. 17, 2011, pages 2216 - 2226, XP055248771, ISSN: 1568-0266
YOUSUKE KANEKO ET AL.: "Transient receptor potential (TRP) channels: a clinical perspective", BRITISH JOURNAL OF PHARMACOLOGY, vol. 171, no. 10, 28 April 2014 (2014-04-28), pages 2474 - 2507, XP055248770, ISSN: 0007-1188
DAIVID G. WASHBURN ET AL.: "The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 17, 26 June 2013 (2013-06-26), pages 4979 - 4984, XP028690063, ISSN: 0960-894x
DATABASE REGISTRY [o] 21 April 2015 (2015-04-21), retrieved from STN Database accession no. 1688730- 42-8
FABIEN VINCENT ET AL.: "TRPV4 Agonists and Antagonists", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 11, no. 17, 2011, pages 2216 - 2226, XP055248771, ISSN: 1568-0266
YOUSUKE KANEKO ET AL.: "Transient receptor potential (TRP) channels: a clinical perspective", BRITISH JOURNAL OF PHARMACOLOGY, vol. 171, no. 10, 28 April 2014 (2014-04-28), pages 2474 - 2507, XP055248770, ISSN: 0007-1188
DAIVID G. WASHBURN ET AL.: "The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 17, 26 June 2013 (2013-06-26), pages 4979 - 4984, XP028690063, ISSN: 0960-894x
DATABASE REGISTRY [o] 21 April 2015 (2015-04-21), retrieved from STN Database accession no. 1688730- 42-8
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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