Title:
2, 4, 6-TRI-SUBSTITUTED PYRIMIDINE COMPOUND AS ATR KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2020/244613
Kind Code:
A1
Abstract:
Compounds of general formula (A) can be used for treating ATR kinase-mediated diseases, for example, hyperplastic diseases such as cancers. Also provided are a pharmaceutical composition of the compounds of general formula (A), a use of the pharmaceutical composition for treating the ATR kinase-mediated diseases and a preparation method for the pharmaceutical composition.
Inventors:
ZHAO YANPING (CN)
WANG HONGJUN (CN)
LIU BIN (CN)
JIANG YUANYUAN (CN)
ZHONG WEITING (CN)
XU HUIFEN (CN)
ZHANG HONGLEI (CN)
HUANG CHUANGCHUANG (CN)
TIAN NANA (CN)
ZHAO JING (CN)
LI JING (CN)
LIU WEINA (CN)
ZHOU LIYING (CN)
LIU YANAN (CN)
WANG HONGJUN (CN)
LIU BIN (CN)
JIANG YUANYUAN (CN)
ZHONG WEITING (CN)
XU HUIFEN (CN)
ZHANG HONGLEI (CN)
HUANG CHUANGCHUANG (CN)
TIAN NANA (CN)
ZHAO JING (CN)
LI JING (CN)
LIU WEINA (CN)
ZHOU LIYING (CN)
LIU YANAN (CN)
Application Number:
PCT/CN2020/094532
Publication Date:
December 10, 2020
Filing Date:
June 05, 2020
Export Citation:
Assignee:
BEIJING TIDE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/04; A61K31/506; A61P35/00; C07D401/14; C07D403/14
Domestic Patent References:
| WO2008032077A1 | 2008-03-20 | |||
| WO2019050889A1 | 2019-03-14 | |||
| WO2011005119A1 | 2011-01-13 | |||
| WO2009093981A1 | 2009-07-30 | |||
| WO2012044641A1 | 2012-04-05 | |||
| WO2019154365A1 | 2019-08-15 |
Foreign References:
| CN101535296A | 2009-09-16 | |||
| CN102448958A | 2012-05-09 | |||
| CN101765597A | 2010-06-30 | |||
| CN101790525A | 2010-07-28 | |||
| CN101010318A | 2007-08-01 | |||
| CN110343095A | 2019-10-18 | |||
| CN110467610A | 2019-11-19 | |||
| US5376645A | 1994-12-27 |
Other References:
BERGE S. M. ET AL.: "Pharmaceutical Salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
M. B. SMITHJ. MARCH: "March' s Advanced Organic Chemistry", 2001, JOHN WILEY & SONS
T. HIGUCHIV. STELLA: "Prodrugs as Novel Delivery Systems, A.C.S. Symposium Series", 1987, PERGAMON PRESS
D. FLEISHERS. RAMONH. BARBRA: "Advanced Drug Delivery Reviews", vol. 19, 1996, article "Improved oral drug delivery: solubility limitations overcome by the use of prodrugs", pages: 115 - 130
"Remington's Pharmaceutical Sciences,", MACK PUBLISHING COMPANY
See also references of EP 3967694A4
M. B. SMITHJ. MARCH: "March' s Advanced Organic Chemistry", 2001, JOHN WILEY & SONS
T. HIGUCHIV. STELLA: "Prodrugs as Novel Delivery Systems, A.C.S. Symposium Series", 1987, PERGAMON PRESS
D. FLEISHERS. RAMONH. BARBRA: "Advanced Drug Delivery Reviews", vol. 19, 1996, article "Improved oral drug delivery: solubility limitations overcome by the use of prodrugs", pages: 115 - 130
"Remington's Pharmaceutical Sciences,", MACK PUBLISHING COMPANY
See also references of EP 3967694A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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