Title:
POLYMORPH OF CDK9 INHIBITOR AND PREPARATION METHOD FOR POLYMORPH AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/244612
Kind Code:
A1
Abstract:
The present invention provides a polymorph of a CDK9 inhibitor and a preparation method for the polymorph and a use thereof. Specifically, disclosed are 4-(((4-(5-chloro-2-(((1R,4r)-4-(((R)-1-methoxy propyl-2-yl)amino)cyclohexyl)amino)pyridine-4-yl)thiazole-2-yl)amino)methyl)tetrahydro-2H-pyrano-4-methylnitrile maleate or fumarate or polymorphs thereof and applications thereof. In addition, also disclosed are a pharmaceutical composition containing the substance and an application of the pharmaceutical composition.
Inventors:
ZHOU FUSHENG (CN)
ZHAO JINZHU (CN)
LAN JIONG (CN)
ZHAO JINZHU (CN)
LAN JIONG (CN)
Application Number:
PCT/CN2020/094527
Publication Date:
December 10, 2020
Filing Date:
June 05, 2020
Export Citation:
Assignee:
GENFLEET THERAPEUTICS SHANGHAI INC (CN)
ZHEJIANG GENFLEET THERAPEUTICS CO LTD (CN)
ZHEJIANG GENFLEET THERAPEUTICS CO LTD (CN)
International Classes:
C07D417/14; A61K31/4439; A61P35/00
Foreign References:
| CN108727363A | 2018-11-02 | |||
| CN108727363A | 2018-11-02 | |||
| CN108727363A | 2018-11-02 |
Other References:
SIMS RJ 3RD ET AL., GENES DEV, vol. 18, 2004, pages 2437 - 68
YAMAGUCHI Y ET AL., MOL CELL BIOL, vol. 22, 2002, pages 2918 - 27
"Crystallization", 1993, BUTTERWORTH-HEINEMAN LTD.
See also references of EP 3981768A4
YAMAGUCHI Y ET AL., MOL CELL BIOL, vol. 22, 2002, pages 2918 - 27
"Crystallization", 1993, BUTTERWORTH-HEINEMAN LTD.
See also references of EP 3981768A4
Attorney, Agent or Firm:
SHANGHAI GOOIP CO., LTD. (CN)
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