2-PHENYLPYRIDINE DERIVATIVE - ASTELLAS PHARMA INC

Title:

2-PHENYLPYRIDINE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2006/022374

Kind Code:

A1

Abstract:

A 2-phenylpyridine derivative represented by the following general formula (I) or a salt thereof. The compounds have satisfactory xanthine oxidase inhibitory activity and uric acid-lowering activity and are useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory intestinal diseases, diabetic nephropathy, diabetic retinopathy, etc. [The symbols in the formula have the following meanings: R¹: H, etc.; R²: -CO₂H, etc.; R³ and R⁴: H, etc.; R⁵: -CN, etc.; R⁶: H, etc.; X: -O-, -N(R⁸)-, or -S-; (provided that the groups represented by R⁵ and -X-R⁷ are bonded in a meta position or the para position to the pyridyl group) R⁸: H, etc.; R⁷: C_1-8 linear or branched alkyl, etc.; Y: a bond, etc.; and R⁹, R¹⁰, and R¹¹: H, etc. (provided that when X is -N(R⁸)-, then R⁸ may be bonded to R⁷ to form a nitrogenous saturated heterocycle in cooperation with the adjacent nitrogen atom).]

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Inventors:

MIYATA JUNJI (JP)
NAITO RYO (JP)
KAWAKAMI MASAKATSU (JP)
ASANO TORU (JP)

Application Number:

PCT/JP2005/015549

Publication Date:

March 02, 2006

Filing Date:

August 26, 2005

Export Citation:

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Assignee:

ASTELLAS PHARMA INC (JP)
MIYATA JUNJI (JP)
NAITO RYO (JP)
KAWAKAMI MASAKATSU (JP)
ASANO TORU (JP)

International Classes:

C07D213/79; A61K31/4418; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4725; A61K31/496; A61K31/498; A61K31/5377; A61K31/541; A61K31/55; A61P1/04; A61P3/10; A61P9/04; A61P9/10; A61P13/04; A61P13/12; A61P19/06; A61P29/00; A61P35/00; A61P43/00; C07D401/04; C07D401/10; C07D401/12; C07D405/12; C07D409/10; C07D413/10; C07D417/10

Domestic Patent References:

WO1992009279A1	1992-06-11
WO1996031211A1	1996-10-10
WO1998018765A1	1998-05-07
WO2002098840A1	2002-12-12
WO2003020703A1	2003-03-13

Foreign References:

JPH0665210A	1994-03-08
JP2002105067A	2002-04-10
JPH10310578A	1998-11-24
JPS5995272A	1984-06-01
JPH06211815A	1994-08-02
JPS5785379A	1982-05-28
JP2000001431A	2000-01-07
US3655679A	1972-04-11

Other References:

CIUSA R ET AL: "Influence of various pyridine derivatives on the elimination of uric acid.", ANNALI DI CHIMICA APPLICATA., vol. 21, 1931, pages 553 - 558, XP008092292

Attorney, Agent or Firm:

Morita, Hiroshi c/o Astellas Pharma Inc. Intellectual Property (3-11, Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, JP)

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