Title:
2-PHENYLTHIOPHENE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2006/022375
Kind Code:
A1
Abstract:
A 2-phenylthiophene derivative represented by the following general formula (I) or a salt thereof, characterized by comprising a thiophene ring substituted by a carboxy group, etc. and a benzene ring having both of an electron-attracting group, e.g., a cyano group, and an electron-donating group, e.g., a substituted alkoxy group. (I) The compound is satisfactory in xanthine oxidase inhibitory activity and uric acid lowering activity and has no structure derived from any nucleic acid. The compound hence has an advantage that it is safer and more effective than conventional compounds. The compound is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory intestinal diseases, diabetic nephropathy, diabetic retinopathy, etc.
Inventors:
MIYATA JUNJI (JP)
YOKOTA MASAKI (JP)
NAITO RYO (JP)
KAMIKAWA AKIO (JP)
KAWAKAMI MASAKATSU (JP)
HATTORI KAZUYUKI (JP)
YOKOTA MASAKI (JP)
NAITO RYO (JP)
KAMIKAWA AKIO (JP)
KAWAKAMI MASAKATSU (JP)
HATTORI KAZUYUKI (JP)
Application Number:
PCT/JP2005/015550
Publication Date:
March 02, 2006
Filing Date:
August 26, 2005
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
MIYATA JUNJI (JP)
YOKOTA MASAKI (JP)
NAITO RYO (JP)
KAMIKAWA AKIO (JP)
KAWAKAMI MASAKATSU (JP)
HATTORI KAZUYUKI (JP)
MIYATA JUNJI (JP)
YOKOTA MASAKI (JP)
NAITO RYO (JP)
KAMIKAWA AKIO (JP)
KAWAKAMI MASAKATSU (JP)
HATTORI KAZUYUKI (JP)
International Classes:
A61K31/381; A61K31/4025; A61K31/404; A61K31/41; A61K31/427; A61K31/4436; A61K31/4535; A61K31/5377; A61K31/541; A61K31/55; A61P1/00; A61P19/06; A61P3/00; A61P3/10; A61P43/00; C07D333/40; C07D409/04; C07D409/10; C07D409/12; C07D417/10; C07D417/12; (IPC1-7): C07D333/40; C07D409/04; C07D409/10; C07D409/12; C07D417/10; C07D417/12; A61K31/381; A61K31/4025; A61K31/404; A61K31/41; A61K31/427; A61K31/4436; A61K31/4535; A61K31/5377; A61K31/541; A61K31/55; A61P1/00; A61P3/00; A61P3/10; A61P19/06; A61P43/00
Foreign References:
| JP2000001431A | 2000-01-07 | |||
| JPH02193990A | 1990-07-31 |
Other References:
NOGUCHI T. ET AL: "Synthesis and structure-activity relantionships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents", BIOORG MED CHEM, vol. 11, no. 22, 2003, pages 4729 - 4742, XP002992944
See also references of EP 1783124A4
See also references of EP 1783124A4
Attorney, Agent or Firm:
Morita, Hiroshi c/o Astellas Pharma Inc. (Intellectual Property 3-11, Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, JP)
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