Title:
2,6-DIBENZYLIDENE CYCLOHEXANONE OXIME COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/236809
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of anti-inflammatory drugs. Disclosed are a 2,6-dibenzylidene cyclohexanone oxime compound, a method for preparing same, and use thereof. According to the present invention, a structural fragment with anti-inflammatory activity is introduced into the 2,6-dibenzylidene cyclohexanone oxime compound, and the prepared compound is stable in physicochemical properties. Experiments show that the 2,6-dibenzylidene cyclohexanone oxime compound has an excellent inhibitory effect on inflammatory factors and better in-vivo anti-inflammatory activity, especially for hepatitis and fatty liver disease caused by TNF-α and/or IL-6 exceeding normal expression and release, and has a protective effect on liver inflammation and liver lipid metabolism.
More Like This:
| WO/1996/004237 | METHOD OF PRODUCING O-(2-HYDROXYALKYL)-OXIMES |
| WO/2002/066419 | PROCESS FOR PRODUCING 2-HALOGENOCYCLOALKANONE OXIME |
| WO/2014/157020 | METHOD FOR PRODUCING OXIME |
Inventors:
LIANG GUANG (CN)
TANG QIDONG (CN)
LUO WU (CN)
WANG XIEMIN (CN)
WU WENQI (CN)
WANG YI (CN)
TANG QIDONG (CN)
LUO WU (CN)
WANG XIEMIN (CN)
WU WENQI (CN)
WANG YI (CN)
Application Number:
PCT/CN2023/097030
Publication Date:
December 14, 2023
Filing Date:
May 30, 2023
Export Citation:
Assignee:
UNIV WENZHOU MEDICAL (CN)
International Classes:
C07C251/44; A61K31/15; A61K31/40; A61P1/16; A61P29/00; C07C249/12; C07C251/52; C07C251/54; C07C251/58; C07D295/088; C07D307/12; C07D309/06
Foreign References:
| CN114853630A | 2022-08-05 | |||
| CN106008324A | 2016-10-12 | |||
| CN101973934A | 2011-02-16 |
Other References:
ISMAIL ZEINAB H: "The use of α-enone derivative in the preparation of some new heterocyclic compounds with expected biological and antitumor activities", ADV. ENVIRON. BIOL., vol. 7, no. 6, 1 January 2013 (2013-01-01), pages 1049 - 1057, XP093114300, ISSN: 1995-0756
QIN, HUALI ET AL.: "Synthesis and mechanistic studies of curcumin analog-based oximes as potential anticancer agents", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 90, no. 3, 10 February 2017 (2017-02-10), pages 443 - 449, XP072377954, ISSN: 1747-0277, DOI: 10.1111/cbdd.12964
QIN, HUALI ET AL.: "Synthesis and mechanistic studies of curcumin analog-based oximes as potential anticancer agents", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 90, no. 3, 10 February 2017 (2017-02-10), pages 443 - 449, XP072377954, ISSN: 1747-0277, DOI: 10.1111/cbdd.12964
Attorney, Agent or Firm:
RZBC PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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