3-ALPHA-HYDROXY 21-N- HETEROARYL-PREGNANE DERIVATIVES FOR MODULATION OF BRAIN EXCITABILITY AND A PROCESS FOR THE PRODUCTION THEREOF

Title:

3-ALPHA-HYDROXY 21-N- HETEROARYL-PREGNANE DERIVATIVES FOR MODULATION OF BRAIN EXCITABILITY AND A PROCESS FOR THE PRODUCTION THEREOF

Document Type and Number:

WIPO Patent Application WO2005105822

Kind Code:

Abstract:

The invention relates to a novel multi step process of making compounds of Formula (I), wherein R

Inventors:

CHANG PING W (US)
ZHONG NING (US)
FANG XINPING (US)
PANG SHAO-KUN (US)
HSIAO CHI-NUNG (US)
HU TSUNG-CHENG

Application Number:

PCT/US2005/014028

Publication Date:

February 02, 2006

Filing Date:

April 22, 2005

Export Citation:

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Assignee:

CHANG PING W (US)
ZHONG NING (US)
FANG XINPING (US)
PANG SHAO-KUN (US)
HSIAO CHI-NUNG (US)
HU TSUNG-CHENG

International Classes:

C07J7/00; C07J43/00; (IPC1-7): C07J43/00; C07J7/00; A61K31/58; A61P25/20; A61P25/22; A61P23/00

Domestic Patent References:

WO2000066614A1	2000-11-09
WO1994027608A1	1994-12-08

Other References:

HOGENKAMP, DERK J. ET AL: "Synthesis and in vitro Activity of 3.beta.-Substituted-3.alpha.- hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor", JOURNAL OF MEDICINAL CHEMISTRY , 40(1), 61-72 CODEN: JMCMAR; ISSN: 0022-2623, 1997, XP002341275
VANOVER K E ET AL: "RESPONSE-RATE SUPPRESSION IN OPERANT PARADIGM AS PREDICTOR OF SOPORIFIC POTENCY IN RATS AND IDENTIFICATION OF THREE NOVEL SEDATIVE-HYPNOTIC NEUROACTIVE STEROIDS", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND, US, vol. 291, no. 3, December 1999 (1999-12-01), pages 1317 - 1323, XP000938328, ISSN: 0022-3565

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