Title:
4-ALKYLRESORCINOL DERIVATIVE AND SKIN-LIGHTENING AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2006/049184
Kind Code:
A1
Abstract:
A 4-alkylresorcinol derivative which is excellent in skin-lightening effect and safety. It is a 4-alkylresorcinol derivative represented by the following general formula (I) or a salt thereof. (In the general formula (I), R1 is branched alkyl selected among 1-ethylpropyl, 1-ethyl-2-methylpropyl, 1-isopropyl-2-methylpropyl, 1-butylpentyl, and 1-isobutyl-3-methylbutyl.) The 4-alkylresorcinol derivative (I) is satisfactorily effective in inhibiting melanin generation and is lowly cytotoxic. The derivative (I) is obtained by reacting an organometallic compound with a 4-acylresorcinol to incorporate an alkyl group into the carbonyl carbon and then reducing the resultant resorcinol compound.
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Inventors:
FUKUNISHI HIROTADA (JP)
HIRUMA TAKUYA (JP)
SUETSUGU MASARU (JP)
SATO KIYOSHI (JP)
HATAO MASATO (JP)
HIRUMA TAKUYA (JP)
SUETSUGU MASARU (JP)
SATO KIYOSHI (JP)
HATAO MASATO (JP)
Application Number:
PCT/JP2005/020137
Publication Date:
May 11, 2006
Filing Date:
November 01, 2005
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
FUKUNISHI HIROTADA (JP)
HIRUMA TAKUYA (JP)
SUETSUGU MASARU (JP)
SATO KIYOSHI (JP)
HATAO MASATO (JP)
FUKUNISHI HIROTADA (JP)
HIRUMA TAKUYA (JP)
SUETSUGU MASARU (JP)
SATO KIYOSHI (JP)
HATAO MASATO (JP)
International Classes:
C07C39/08; A61K8/00; A61K8/02; A61K8/06; A61K8/30; A61Q19/00; C07C37/11
Domestic Patent References:
| WO2004052329A1 | 2004-06-24 |
Foreign References:
| JP2004010598A | 2004-01-15 | |||
| JPH0249715A | 1990-02-20 | |||
| JP2003300855A | 2003-10-21 | |||
| JPH02240037A | 1990-09-25 |
Other References:
MCENROE F J ET AL: "Structures and synthesis of some new antibacterial sesquiterpenoids from the gorgonian coral Pseudopterogorgia rigida.", TETRAHEDRON., vol. 34, no. 11, 1978, pages 1661 - 1664, XP002995298
Attorney, Agent or Firm:
Iwahashi, Yuji (Kanagawa Kanagawa-k, Yokohama-shi Kanagawa 45, JP)
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