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Title:
4-ISOPROPYL-6-METHOXYPHENYL GLUCITOL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2012/023600
Kind Code:
A1
Abstract:
Provided is a compound for inhibiting abnormal glucose intolerance and postprandial hyperglycemia in diabetic patients by inhibiting the activity of sodium-glucose transporter 1 (SGLT 1) and the absorption of glucose. Specifically provided are a 4-isopropyl-6-methoxyphenyl glucitol compound represented by formula (I) and a pharmaceutically acceptable salt of said compound.

Inventors:
KAKINUMA HIROYUKI (JP)
KOBASHI YOHEI (JP)
CHONAN TOMOMICHI (JP)
SHIOZAWA FUMIYASU (JP)
IWATA YUKI (JP)
OI TAKAHIRO (JP)
KAWABE KENICHI (JP)
Application Number:
PCT/JP2011/068738
Publication Date:
February 23, 2012
Filing Date:
August 19, 2011
Export Citation:
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Assignee:
TAISHO PHARMA CO LTD (JP)
KAKINUMA HIROYUKI (JP)
KOBASHI YOHEI (JP)
CHONAN TOMOMICHI (JP)
SHIOZAWA FUMIYASU (JP)
IWATA YUKI (JP)
OI TAKAHIRO (JP)
KAWABE KENICHI (JP)
International Classes:
C07D309/10; A61K31/351; A61P3/10; A61P43/00
Domestic Patent References:
WO2002098893A12002-12-12
WO2004014932A12004-02-19
WO2004018491A12004-03-04
WO2004019958A12004-03-11
WO2005121161A12005-12-22
WO2004050122A12004-06-17
WO2007136116A22007-11-29
WO2007013611A12007-02-01
Foreign References:
JP2009537509A2009-10-29
JP2009107948A2009-05-21
JP2009107947A2009-05-21
Other References:
See also references of EP 2607360A4
PAN XR ET AL., DIABETES CARE, vol. 20, 1997, pages 537
M TOMINAGA ET AL., DIABETES CARE, vol. 22, 1999, pages 920
J.-L. CHIASSON ET AL., LANCENT, vol. 359, 2002, pages 2072
E. M. WRIGHT, AM. J. PHYSIOL. RENAL. PHYSIOL., vol. 280, 2001, pages F10
G.. TOGGENBURGER ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 688, 1982, pages 557
FOLIA PHARMACOL. JPN., vol. 113, 1999, pages 19
J. ORG. CHEM., vol. 65, 2000, pages 8402
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
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Claims: