5-HT2A RECEPTOR INVERSE AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF

WIPO Patent Application WO/2024/027800

A1

The present invention relates to a new compound as a 5-HT2A receptor inverse agonist, a preparation method therefor and a pharmaceutical composition. The present invention further relates to the use of the compound or the pharmaceutical composition in the preparation of a drug for treating 5-HT2A receptor-related diseases. The diseases include non-motor symptoms caused by Parkinson's disease: delusions, hallucination, depression, anxiety, cognitive impairment and sleep disorders; dementia-related mental diseases; severe depression; or negative symptoms of schizophrenia, etc.

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TIAN JINGWEI (CN)
YE LIANG (CN)
MA MINGXU (CN)
WANG WENYAN (CN)
DU GUANGYING (CN)
ZHANG JIANZHAO (CN)
DAI YUSEN (CN)
ZHANG RUI (CN)

PCT/CN2023/111052

February 08, 2024

August 03, 2023

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GENEORA PHARMA SHIJIAZHUANG CO LTD (CN)

C07D401/12; A61K31/4535; A61K31/454; A61K31/4545; A61P25/06; A61P25/18; A61P25/22; A61P25/24; A61P25/28; C07D211/58; C07D211/76; C07D405/12; C07D413/12; C07D471/04

WO2022017440A1	2022-01-27
WO2019040106A2	2019-02-28

CN111132976A

2020-05-08

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