6-SUBSTITUTED PROSTAGLANDIN E1'S AND PROCESS FOR THEIR PREPARATION

Title:

6-SUBSTITUTED PROSTAGLANDIN E1'S AND PROCESS FOR THEIR PREPARATION

Document Type and Number:

WIPO Patent Application WO/1985/003935

Kind Code:

A1

Abstract:

6-substituted prostaglandin E1's represented by formula (I), (wherein R1 represents H, C1 to C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted C3 to C10 cycloalkyl, substituted or unsubstituted phenyl(C1 to C2) alkyl or mono-equivalent cation; R2 and R3, which may be the same or different, each represents H, tri(C1 to C7)hydrocarbylsilyl, or a group forming an acetal bond with the oxygen atom of the hydroxy group, R4 represents H, methyl or vinyl, R5 represents straight or branched C3 to C8 alkyl, straight or branched C3 to C8 alkenyl, straight or branched C3 to C8 alkynyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted C3 to C10 cycloalkyl or C1 to C6 alkoxy, straight or branched C1 to C5 alkyl substituted by optionally substituted phenyl, optionally substituted phenoxy or optionally substituted C3 to C10 cycloalkyl, and X represents H-NO2 or oxygen atom), enantiomers thereof, and mixtures thereof in arbritary ratios, are useful for treating and preventing diseases of digestive organs such as duodenum or stomach.

Inventors:

TANAKA TOSHIO (JP)
HAZATO ATSUO (JP)
KUROZUMI SEIJI (JP)

Application Number:

PCT/JP1985/000096

Publication Date:

September 12, 1985

Filing Date:

February 28, 1985

Export Citation:

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Assignee:

TEIJIN LTD (JP)

International Classes:

A61K31/557; A61K31/5575; C07F7/18; A61P43/00; C07C67/00; C07C401/00; C07C405/00; C07F1/02; C07F1/08; (IPC1-7): C07C177/00; A61K31/557

Foreign References:

JPS55141465A	1980-11-05
JPS5936657A	1984-02-28
JPS5444639A	1979-04-09

Other References: