7-(3,5-DIISOPROPYLPHENYL) HEPTATRIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY

Title:

7-(3,5-DIISOPROPYLPHENYL) HEPTATRIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY

Document Type and Number:

WIPO Patent Application WO2004069781

Kind Code:

A3

Abstract:

Compounds of formula (i) where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effect of reducing serum thyroxine levels.

Inventors:

VASUDEVAN JAYASREE (US)
BEARD RICHARD L (US)
YUAN HAIQING (US)
CHANDRARATNA ROSHANTHA A (US)

Application Number:

PCT/US2004/003160

Publication Date:

September 30, 2004

Filing Date:

February 03, 2004

Export Citation:

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Assignee:

ALLERGAN INC (US)
VASUDEVAN JAYASREE (US)
BEARD RICHARD L (US)
YUAN HAIQING (US)
CHANDRARATNA ROSHANTHA A (US)

International Classes:

A61P3/10; C07C59/68; C07C69/734; (IPC1-7): C07C59/64; A61K31/202; A61K31/216; A61P3/10; C07C69/734

Foreign References:

US6114533A

2000-09-05

Other References:

P.Y. MICHELLYS ET AL: "Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes", J. MED. CHEM., vol. 46, 2003, pages 2683 - 2696, XP002287783
D.L. GERNERT ET AL: "Design and Synthesis of Fluorinated RXR Modulators", BIOORG. MED. CHEM. LETT., vol. 13, 2003, pages 3191 - 3195, XP002287784

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