Title:
2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Document Type and Number:
WIPO Patent Application WO2004069782
Kind Code:
A3
Abstract:
Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. In particular, 2(ortho)-substituted arylacetic acids or their derivatives, such as amides and sulfonamides, lack cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.
Inventors:
MORICONI ALESSIO (IT)
ALLEGRETTI MARCELLO (IT)
BERTINI RICCARDO (IT)
CESTA MARIA CANDIDA (IT)
BIZZARRI CINZIA (IT)
COLOTTA FRANCESCO (IT)
ALLEGRETTI MARCELLO (IT)
BERTINI RICCARDO (IT)
CESTA MARIA CANDIDA (IT)
BIZZARRI CINZIA (IT)
COLOTTA FRANCESCO (IT)
Application Number:
PCT/EP2004/001021
Publication Date:
September 16, 2004
Filing Date:
February 04, 2004
Export Citation:
Assignee:
DOMPE SPA (IT)
MORICONI ALESSIO (IT)
ALLEGRETTI MARCELLO (IT)
BERTINI RICCARDO (IT)
CESTA MARIA CANDIDA (IT)
BIZZARRI CINZIA (IT)
COLOTTA FRANCESCO (IT)
MORICONI ALESSIO (IT)
ALLEGRETTI MARCELLO (IT)
BERTINI RICCARDO (IT)
CESTA MARIA CANDIDA (IT)
BIZZARRI CINZIA (IT)
COLOTTA FRANCESCO (IT)
International Classes:
C07C59/205; C07C63/04; C07C65/32; C07C311/02; C07C311/09; C07C311/21; C07C311/29; C07C311/51; C07D207/32; C07D207/337; C07D209/26; C07D209/42; C07D295/12; C07D295/13; C07D471/04; (IPC1-7): C07C63/04; C07C59/205; C07C65/32; C07C311/02; C07C311/29; C07D207/32; C07D209/42; C07D295/12
Domestic Patent References:
| WO2001058852A2 | 2001-08-16 | |||
| WO2002068377A1 | 2002-09-06 |
Foreign References:
| FR1574570A | 1969-07-11 |
Other References:
BRANCACCIO G ET AL: "2-(Arylmethyl)arylacetic Acids as Potential Antiinflammatory Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 24, 1981, pages 998 - 1000, XP002236682, ISSN: 0022-2623
WALSH, DAVIS ET AL.: "Antiinflammatory agents- Synthesis and activity of substituted 2-aminophenylacetic acid derivatives", J.MED.CHEM., vol. 25, no. 4, 1982, pages 446 - 451, XP002288769
WALSH, DAVIS ET AL.: "Antiinflammatory agents- Synthesis and activity of substituted 2-aminophenylacetic acid derivatives", J.MED.CHEM., vol. 25, no. 4, 1982, pages 446 - 451, XP002288769
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