Title:
ANTI-DXd ANTIBODIES AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2023/143387
Kind Code:
A1
Abstract:
Provided are antigen-binding fragments thereof that bind to DXd, and use of the antibody for detection and assay of DXd.
Inventors:
LI DAN (CN)
TANG XIAOYAN (CN)
TSAI CHARNG-SHENG (CN)
TSAI MEI-HSUAN (CN)
TANG XIAOYAN (CN)
TSAI CHARNG-SHENG (CN)
TSAI MEI-HSUAN (CN)
Application Number:
PCT/CN2023/073187
Publication Date:
August 03, 2023
Filing Date:
January 19, 2023
Export Citation:
Assignee:
BEIGENE LTD (GB)
LI DAN (CN)
LI DAN (CN)
International Classes:
C07K16/44; C12N1/21; C12N15/13; G01N33/53
Domestic Patent References:
| WO2021200131A1 | 2021-10-07 | |||
| WO2020240467A1 | 2020-12-03 |
Foreign References:
| US20200390900A1 | 2020-12-17 |
Other References:
NAGAI YOKO, OITATE MASATAKA, SHIOZAWA HIDEYUKI, ANDO OSAMU: "Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys", XENOBIOTICA, TAYLOR AND FRANCIS, LONDON,, UK, vol. 49, no. 9, 2 September 2019 (2019-09-02), UK , pages 1086 - 1096, XP009547668, ISSN: 0049-8254, DOI: 10.1080/00498254.2018.1531158
SUZUKI MIKIKO, YAGISHITA SHIGEHIRO, SUGIHARA KIYOSHI, OGITANI YUSUKE, NISHIKAWA TADAAKI, OHUCHI MAYU, TEISHIKATA TAKASHI, JIKOH TA: "Visualization of Intratumor Pharmacokinetics of [fam-] Trastuzumab Deruxtecan (DS-8201a) in HER2 Heterogeneous Model Using Phosphor-integrated Dots Imaging Analysis", CLINICAL CANCER RESEARCH, ASSOCIATION FOR CANCER RESEARCH, US, vol. 27, no. 14, 15 July 2021 (2021-07-15), US, pages 3970 - 3979, XP093081096, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-21-0397
OKAJIMA DAISUKE, YASUDA SATORU, MAEJIMA TAKANORI, KARIBE TSUYOSHI, SAKURAI KEN, AIDA TETSUO, TOKI TADASHI, YAMAGUCHI JUNKO, KITAMU: "Datopotamab Deruxtecan, a Novel TROP2-directed Antibody–drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 20, no. 12, 1 December 2021 (2021-12-01), US , pages 2329 - 2340, XP055921509, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-21-0206
OGITANI YUSUKE, ABE YUKI, IGUCHI TAKUMA, YAMAGUCHI JUNKO, TERAUCHI TOMOKO, KITAMURA MICHIKO, GOTO KOICHI, GOTO MAYUMI, OITATE MASA: "Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 26, no. 20, 1 October 2016 (2016-10-01), Amsterdam NL , pages 5069 - 5072, XP055852728, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.08.082
SUZUKI MIKIKO, YAGISHITA SHIGEHIRO, SUGIHARA KIYOSHI, OGITANI YUSUKE, NISHIKAWA TADAAKI, OHUCHI MAYU, TEISHIKATA TAKASHI, JIKOH TA: "Visualization of Intratumor Pharmacokinetics of [fam-] Trastuzumab Deruxtecan (DS-8201a) in HER2 Heterogeneous Model Using Phosphor-integrated Dots Imaging Analysis", CLINICAL CANCER RESEARCH, ASSOCIATION FOR CANCER RESEARCH, US, vol. 27, no. 14, 15 July 2021 (2021-07-15), US, pages 3970 - 3979, XP093081096, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-21-0397
OKAJIMA DAISUKE, YASUDA SATORU, MAEJIMA TAKANORI, KARIBE TSUYOSHI, SAKURAI KEN, AIDA TETSUO, TOKI TADASHI, YAMAGUCHI JUNKO, KITAMU: "Datopotamab Deruxtecan, a Novel TROP2-directed Antibody–drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 20, no. 12, 1 December 2021 (2021-12-01), US , pages 2329 - 2340, XP055921509, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-21-0206
OGITANI YUSUKE, ABE YUKI, IGUCHI TAKUMA, YAMAGUCHI JUNKO, TERAUCHI TOMOKO, KITAMURA MICHIKO, GOTO KOICHI, GOTO MAYUMI, OITATE MASA: "Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 26, no. 20, 1 October 2016 (2016-10-01), Amsterdam NL , pages 5069 - 5072, XP055852728, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.08.082
Attorney, Agent or Firm:
WU , FENG & ZHANG (CN)
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