Title:
AMIDE COMPOUND AS POTASSIUM CHANNEL REGULATOR, AND PREPARATION THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/143388
Kind Code:
A1
Abstract:
Provided are an amide compound as a potassium channel regulator, and the preparation therefor and the use thereof. The compound has a structure as represented by formula I, wherein the definition of each group and substituent is as described in the description.
Inventors:
LIANG BO (CN)
LIU GANG (CN)
JIANG ZHAOJIAN (CN)
HUANG MENGWEI (CN)
CHEN HUANMING (CN)
LIU GANG (CN)
JIANG ZHAOJIAN (CN)
HUANG MENGWEI (CN)
CHEN HUANMING (CN)
Application Number:
PCT/CN2023/073191
Publication Date:
August 03, 2023
Filing Date:
January 19, 2023
Export Citation:
Assignee:
SHANGHAI ZHIMENG BIOPHARMA INC (CN)
International Classes:
C07D401/04; A61K31/165; A61K31/4353; A61P25/28; C07D405/02
Domestic Patent References:
| WO2010094645A1 | 2010-08-26 |
Foreign References:
| CN101868451A | 2010-10-20 | |||
| CN101778848A | 2010-07-14 | |||
| CN109641836A | 2019-04-16 | |||
| CN101056845A | 2007-10-17 | |||
| CN110511220A | 2019-11-29 | |||
| CN101790374A | 2010-07-28 | |||
| CN113698345A | 2021-11-26 | |||
| CN103694163A | 2014-04-02 | |||
| ES2359601T3 | 2011-05-25 | |||
| US20210213009A1 | 2021-07-15 | |||
| CN102869250A | 2013-01-09 |
Other References:
HANSEN FINN K., GEFFKEN DETLEF: "Efficient synthesis of flupirtine analogues derived from pyrimidine", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 49, no. 2, 1 March 2012 (2012-03-01), US , pages 321 - 328, XP093082052, ISSN: 0022-152X, DOI: 10.1002/jhet.725
YANG, SHAONING ET AL.: "Design, synthesis and evaluation of novel N-phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 28, 16 May 2018 (2018-05-16), XP085447049, DOI: 10.1016/j.bmcl.2018.05.019
SURUR ABDRRAHMAN S., BOCK CHRISTIAN, BEIROW KRISTIN, WURM KONRAD, SCHULIG LUKAS, KINDERMANN MARKUS K., SIEGMUND WERNER, BEDNARSKI : "Flupirtine and retigabine as templates for ligand-based drug design of KV7.2/3 activators", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 17, no. 18, 8 May 2019 (2019-05-08), pages 4512 - 4522, XP093082055, ISSN: 1477-0520, DOI: 10.1039/C9OB00511K
YANG, SHAONING ET AL.: "Design, synthesis and evaluation of novel N-phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 28, 16 May 2018 (2018-05-16), XP085447049, DOI: 10.1016/j.bmcl.2018.05.019
SURUR ABDRRAHMAN S., BOCK CHRISTIAN, BEIROW KRISTIN, WURM KONRAD, SCHULIG LUKAS, KINDERMANN MARKUS K., SIEGMUND WERNER, BEDNARSKI : "Flupirtine and retigabine as templates for ligand-based drug design of KV7.2/3 activators", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 17, no. 18, 8 May 2019 (2019-05-08), pages 4512 - 4522, XP093082055, ISSN: 1477-0520, DOI: 10.1039/C9OB00511K
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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