Title:
ACCELERATOR FOR INITIAL INSULIN SECRETION
Document Type and Number:
WIPO Patent Application WO/2005/027891
Kind Code:
A1
Abstract:
An accelerator for initial insulin secretion which contains a triterpene represented by the following general formula (1) and/or a triterpene represented by the following general formula (2).[Chemical formula 1] [In the formulae, R1 is COOH, etc.; R11 and R12 each is CH2OH, etc.; X1 is hydrogen or OH; and X11, X12, X21, and X22 each is OH, etc.]
Inventors:
MATSUYAMA FUTOSHI (JP)
SEINO YUTAKA (JP)
MIURA TOSHIHIRO (JP)
FUJITA TAKESHI (JP)
KANEKO TETSUO (JP)
SEINO YUTAKA (JP)
MIURA TOSHIHIRO (JP)
FUJITA TAKESHI (JP)
KANEKO TETSUO (JP)
Application Number:
PCT/JP2004/013836
Publication Date:
March 31, 2005
Filing Date:
September 22, 2004
Export Citation:
Assignee:
USE TECHNO CORP (JP)
MATSUYAMA FUTOSHI (JP)
SEINO YUTAKA (JP)
FUKUSHIMA MITSUO (JP)
MIURA TOSHIHIRO (JP)
FUJITA TAKESHI (JP)
KANEKO TETSUO (JP)
MATSUYAMA FUTOSHI (JP)
SEINO YUTAKA (JP)
FUKUSHIMA MITSUO (JP)
MIURA TOSHIHIRO (JP)
FUJITA TAKESHI (JP)
KANEKO TETSUO (JP)
International Classes:
A23K1/16; A61K31/19; A61K31/20; A61K31/215; A61K31/704; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P9/12; C07C61/28; (IPC1-7): A61K31/19; A61K31/215; A61P3/10; A61P5/50
Domestic Patent References:
| WO2002078468A1 | 2002-10-10 | |||
| WO2002052956A1 | 2002-07-11 | |||
| WO2002043736A1 | 2002-06-06 |
Foreign References:
| US20030165581A1 | 2003-09-04 | |||
| JP2001213778A | 2001-08-07 |
Other References:
IVORRA M.D. ET AL.: "Effect of tormentic acid on insulin secretion in isolated rat islets of Langerhans", PHYTOTHERAPY RESEARCH, vol. 3, no. 4, 1989, pages 145 - 147, XP002984274
IVORRA M.D. ET AL.: "Hypogylcemic and insulin release effects of tormentic acid: a new hypoglycemic natural product", PLANTA MEDICA, vol. 54, no. 4, 1988, pages 282 - 286, XP002984275
YAMAGUCHI T. ET AL.: "The cytotoxic principles of Hyptis Capitata and the structure of the new triterpenes hyptatic acid-A and -B", PHYTOCHEMISTRY, vol. 27, no. 10, 1988, pages 3213 - 3216, XP002984276
IVORRA M.D. ET AL.: "Hypogylcemic and insulin release effects of tormentic acid: a new hypoglycemic natural product", PLANTA MEDICA, vol. 54, no. 4, 1988, pages 282 - 286, XP002984275
YAMAGUCHI T. ET AL.: "The cytotoxic principles of Hyptis Capitata and the structure of the new triterpenes hyptatic acid-A and -B", PHYTOCHEMISTRY, vol. 27, no. 10, 1988, pages 3213 - 3216, XP002984276
Attorney, Agent or Firm:
Hasegawa, Yoshiki (Ginza First Bldg. 10-6, Ginza 1-chome, Chuo-k, Tokyo 61, JP)
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