Title:
EARLY INSULIN SECRETION PROMOTER
Document Type and Number:
WIPO Patent Application WO/2005/027892
Kind Code:
A1
Abstract:
An early insulin secretion promoter comprising corosolic acid and so on. By using this early insulin secretion promoter, insulin can be quickly secreted immediately after eating and, moreover, excessive insulin secretion can be inhibited when blood glucose level shows no increase.
Inventors:
MATSUYAMA FUTOSHI (JP)
SEINO YUTAKA (JP)
FUKUSHIMA MITSUO (JP)
MIURA TOSHIHIRO (JP)
FUJITA TAKESHI (JP)
KANEKO TETSUO (JP)
SEINO YUTAKA (JP)
FUKUSHIMA MITSUO (JP)
MIURA TOSHIHIRO (JP)
FUJITA TAKESHI (JP)
KANEKO TETSUO (JP)
Application Number:
PCT/JP2004/013848
Publication Date:
March 31, 2005
Filing Date:
September 22, 2004
Export Citation:
Assignee:
USE TECHNO CORP (JP)
MATSUYAMA FUTOSHI (JP)
SEINO YUTAKA (JP)
FUKUSHIMA MITSUO (JP)
MIURA TOSHIHIRO (JP)
FUJITA TAKESHI (JP)
KANEKO TETSUO (JP)
MATSUYAMA FUTOSHI (JP)
SEINO YUTAKA (JP)
FUKUSHIMA MITSUO (JP)
MIURA TOSHIHIRO (JP)
FUJITA TAKESHI (JP)
KANEKO TETSUO (JP)
International Classes:
A23K1/16; A61K31/19; A61K31/20; A61K31/215; A61K31/704; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P9/12; C07C61/28; (IPC1-7): A61K31/19; A23K1/16; A23L1/30; A24B15/10; A61K31/215; A61K31/704; A61P3/04; A61P3/06; A61P5/50; A61P9/12
Domestic Patent References:
| WO2002078468A1 | 2002-10-10 |
Foreign References:
| US20030165581A1 | 2003-09-04 | |||
| JP2001213778A | 2001-08-07 | |||
| JPS5371055A | 1978-06-24 | |||
| JP2000086644A | 2000-03-28 | |||
| JPH08214895A | 1996-08-27 | |||
| JPH093089A | 1997-01-07 |
Other References:
IVORRA M. D. ET AL.: "Effect of Tormentic Acid on Insulin Secretion in Isolated Rat Islets of Langerhans", PHYTOTHERAPY RESEARCH, vol. 3, no. 4, 1989, pages 145 - 147, XP002904574
IVORRA M. D. ET AL.: "Hypoglycemic and Insulin Release Effects of Tormentic Acid: A New Hypoglycemic Natural Product", PLANTA MEDICA, vol. 54, no. 4, 1988, pages 282 - 286, XP002904575
YAMAGUCHI T. ET AL.: "The Cytotoxic Principles of Hyptis Capitata and the Structure of the New Triterpenes Hyptatic Acid-A and -B", PHYTOCHEMISTRY, vol. 27, no. 10, 1988, pages 3213 - 3216, XP002904576
VARMA R. S. ET AL.: "Triterpenoids of Callistemon Lanceolatus Leaves", PHYTOCHEMISTRY, vol. 14, 1975, pages 1675 - 1676, XP002904577
TALAPATRA B. ET AL.: "Lagerenyl Acetate and Lagerenol, Two Tetracyclic Triterpenoids with the Cycloartane Skeleton from Lagerstroemia Lancasteri", PHYTOCHEMISTRY, vol. 22, no. 11, 1983, pages 2559 - 2562, XP002904578
IVORRA M. D. ET AL.: "Hypoglycemic and Insulin Release Effects of Tormentic Acid: A New Hypoglycemic Natural Product", PLANTA MEDICA, vol. 54, no. 4, 1988, pages 282 - 286, XP002904575
YAMAGUCHI T. ET AL.: "The Cytotoxic Principles of Hyptis Capitata and the Structure of the New Triterpenes Hyptatic Acid-A and -B", PHYTOCHEMISTRY, vol. 27, no. 10, 1988, pages 3213 - 3216, XP002904576
VARMA R. S. ET AL.: "Triterpenoids of Callistemon Lanceolatus Leaves", PHYTOCHEMISTRY, vol. 14, 1975, pages 1675 - 1676, XP002904577
TALAPATRA B. ET AL.: "Lagerenyl Acetate and Lagerenol, Two Tetracyclic Triterpenoids with the Cycloartane Skeleton from Lagerstroemia Lancasteri", PHYTOCHEMISTRY, vol. 22, no. 11, 1983, pages 2559 - 2562, XP002904578
Attorney, Agent or Firm:
Hasegawa, Yoshiki (Ginza First Bldg. 10-6, Ginza 1-chome, Chuo-k, Tokyo 61, JP)
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