Title:
ACCURATE AND HIGHLY SENSITIVE METHOD FOR MEASURING ACTIVITY OF HUMAN FGF19 AND AGENT FOR REGULATING ACTIVITY OF HUMAN FGF19
Document Type and Number:
WIPO Patent Application WO/2012/086809
Kind Code:
A1
Abstract:
Provided is a method for accurately measuring the activity of human FGF19 through human FGFR in an in vivo human environment. Also provided are a screening method for a human FGF19-like substance or a substance which selectively enhances or suppresses only the activity of human FGF19 to activate human FGFR4 in the coexistence of human beta-Klotho, a kit therefor, and an agent for selectively enhancing or suppressing the activity of human FGF19 to activate human FGFR4 in the coexistence of human beta-Klotho.
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Inventors:
SUZUKI MASASHI (JP)
IMAMURA TORU (JP)
NAKAMURA MASAO (JP)
ASADA MASAHIRO (JP)
KURAMOCHI AKIKO (JP)
HONDA EMI (JP)
UEHARA YURIKO (JP)
IMAMURA TORU (JP)
NAKAMURA MASAO (JP)
ASADA MASAHIRO (JP)
KURAMOCHI AKIKO (JP)
HONDA EMI (JP)
UEHARA YURIKO (JP)
Application Number:
PCT/JP2011/079927
Publication Date:
June 28, 2012
Filing Date:
December 22, 2011
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
SUZUKI MASASHI (JP)
IMAMURA TORU (JP)
NAKAMURA MASAO (JP)
ASADA MASAHIRO (JP)
KURAMOCHI AKIKO (JP)
HONDA EMI (JP)
UEHARA YURIKO (JP)
SUZUKI MASASHI (JP)
IMAMURA TORU (JP)
NAKAMURA MASAO (JP)
ASADA MASAHIRO (JP)
KURAMOCHI AKIKO (JP)
HONDA EMI (JP)
UEHARA YURIKO (JP)
International Classes:
C12Q1/02; A61K31/726; A61K45/00; A61P1/12; G01N33/15; G01N33/50; C12N5/10; C12N15/09
Foreign References:
| JP2010150232A | 2010-07-08 |
Other References:
WALTERS J.R. ET AL.: "A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis", CLIN GASTROENTEROL HEPATOL., vol. 7, no. 11, November 2009 (2009-11-01), pages 1189 - 1194, XP026732493, DOI: doi:10.1016/j.cgh.2009.04.024
LUO Y. ET AL.: "Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation", J BIOL CHEM., vol. 285, no. 39, 24 September 2010 (2010-09-24), pages 30069 - 30078
ZHANG Y. ET AL.: "Genomic organization of the human fibroblast growth factor receptor 2 (FGFR2) gene and comparative analysis of the human FGFR gene family", GENE, vol. 230, no. 1, 1 April 1999 (1999-04-01), pages 69 - 79, XP004165535, DOI: doi:10.1016/S0378-1119(99)00047-5
LUO Y. ET AL.: "Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation", J BIOL CHEM., vol. 285, no. 39, 24 September 2010 (2010-09-24), pages 30069 - 30078
ZHANG Y. ET AL.: "Genomic organization of the human fibroblast growth factor receptor 2 (FGFR2) gene and comparative analysis of the human FGFR gene family", GENE, vol. 230, no. 1, 1 April 1999 (1999-04-01), pages 69 - 79, XP004165535, DOI: doi:10.1016/S0378-1119(99)00047-5
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