Title:
ACELLULAR DERMAL TISSUE PREPARED USING SUPERCRITICAL FLUID EXTRACTION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/195633
Kind Code:
A1
Abstract:
The present invention relates to decellularized acellular dermal tissue prepared using supercritical fluid extraction. More specifically, the present invention relates to an acellular dermal tissue having an improved level of extracellular matrix preservation and optimized mechanical properties such as critical load and elastic restoring force by using supercritical fluid extraction. The acellular dermal tissue according to the present invention is obtained through decellularization without a surfactant treatment so that mechanical properties are maintained, does not possess toxicity resulting from residual surfactants and minimizes transplant rejection, and thus can be effectively used for treatment of patients with damaged skin tissue.
Inventors:
SHIN YONG WOO (KR)
HAN JEONG HUN (KR)
NOH SEONG-RAE (KR)
HAN JEONG HUN (KR)
NOH SEONG-RAE (KR)
Application Number:
PCT/KR2023/002604
Publication Date:
October 12, 2023
Filing Date:
February 23, 2023
Export Citation:
Assignee:
DOF INC (KR)
International Classes:
A61L27/36; A61F2/02
Foreign References:
| CN111265718A | 2020-06-12 | |||
| KR20140024905A | 2014-03-03 |
Other References:
CHOU PING-RUEY, LIN YUN-NAN, WU SHENG-HUA, LIN SIN-DAW, SRINIVASAN PERIASAMY, HSIEH DAR-JEN, HUANG SHU-HUNG: "Supercritical Carbon Dioxide-decellularized Porcine Acellular Dermal Matrix combined with Autologous Adipose-derived Stem Cells: Its Role in Accelerated Diabetic Wound Healing", INTERNATIONAL JOURNAL OF MEDICAL SCIENCE, IVYSPRING INTERNATIONAL PUBLISHER, LAKE HAVEN, AU, vol. 17, no. 3, 1 January 2020 (2020-01-01), AU , pages 354 - 367, XP093097338, ISSN: 1449-1907, DOI: 10.7150/ijms.41155
WANG CHIH-HSIN, HSIEH DAR-JEN, PERIASAMY SRINIVASAN, CHUANG CHAO-TANG, TSENG FAN-WEI, KUO JER-CHENG, TARNG YIH-WEN: "Regenerative porcine dermal collagen matrix developed by supercritical carbon dioxide extraction technology: Role in accelerated wound healing", MATERIALIA, ELSEVIER, vol. 9, 1 March 2020 (2020-03-01), pages 100576, XP093097339, ISSN: 2589-1529, DOI: 10.1016/j.mtla.2019.100576
GIANG NGUYEN NGAN, TRINH XUAN‐TUNG, HAN JEONGHUN, CHIEN PHAM NGOC, LEE JUA, NOH SEONG‐RAE, SHIN YONGWOO, NAM SUN‐YOUNG, HEO CHAN‐Y: "Effective decellularization of human skin tissue for regenerative medicine by supercritical carbon dioxide technique", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, JOHN WILEY & SONS, US, vol. 16, no. 12, 1 December 2022 (2022-12-01), US , pages 1196 - 1207, XP093097341, ISSN: 1932-6254, DOI: 10.1002/term.3359
WANG CHIH-HSIN, HSIEH DAR-JEN, PERIASAMY SRINIVASAN, CHUANG CHAO-TANG, TSENG FAN-WEI, KUO JER-CHENG, TARNG YIH-WEN: "Regenerative porcine dermal collagen matrix developed by supercritical carbon dioxide extraction technology: Role in accelerated wound healing", MATERIALIA, ELSEVIER, vol. 9, 1 March 2020 (2020-03-01), pages 100576, XP093097339, ISSN: 2589-1529, DOI: 10.1016/j.mtla.2019.100576
GIANG NGUYEN NGAN, TRINH XUAN‐TUNG, HAN JEONGHUN, CHIEN PHAM NGOC, LEE JUA, NOH SEONG‐RAE, SHIN YONGWOO, NAM SUN‐YOUNG, HEO CHAN‐Y: "Effective decellularization of human skin tissue for regenerative medicine by supercritical carbon dioxide technique", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, JOHN WILEY & SONS, US, vol. 16, no. 12, 1 December 2022 (2022-12-01), US , pages 1196 - 1207, XP093097341, ISSN: 1932-6254, DOI: 10.1002/term.3359
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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