Title:
METHOD FOR PREDICTING COLORECTAL CANCER PROGNOSIS USING MRNA OF HSPD1 GENE OR HSP60 PROTEIN ENCODED BY THESE GENES
Document Type and Number:
WIPO Patent Application WO/2023/195632
Kind Code:
A1
Abstract:
The present invention relates to: a biomarker for predicting the prognosis of colorectal cancer by using changes in expression level of mRNA of a HSPD1 gene or a HSP60 protein encoded by these genes; and a prognosis prediction method using same. By analyzing the expression level of the HSPD1 gene or the HSP60 protein, the prognoses of colorectal cancer patients can be predicted in clinical practice, and when analysis is carried out in combination with TNM classification, more sophisticated prediction is possible and personalized strategies can be designed.
Inventors:
KIM JUNG HO (KR)
Application Number:
PCT/KR2023/002486
Publication Date:
October 12, 2023
Filing Date:
February 21, 2023
Export Citation:
Assignee:
GIL MEDICAL CT (KR)
International Classes:
C12Q1/6886; G01N33/574
Foreign References:
| KR20210061961A | 2021-05-28 |
Other References:
VOCKA MICHAL, LANGER DANIEL, FRYBA VLADIMIR, PETRTYL JAROMIR, HANUS TOMAS, KALOUSOVA MARTA, ZIMA TOMAS, PETRUZELKA LUBOS: "Novel serum markers HSP60, CHI3L1, and IGFBP-2 in metastatic colorectal cancer", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, GR , XP093097453, ISSN: 1792-1074, DOI: 10.3892/ol.2019.10925
RUAN WENJING; WANG YINGHONG; MA YU; XING XIAOMING; LIN JIE; CUI JING; LAI MAODE: "HSP60, a protein downregulated by IGFBP7 in colorectal carcinoma", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, BIOMED CENTRAL LTD, LONDON UK, vol. 29, no. 1, 30 April 2010 (2010-04-30), London UK , pages 41, XP021083448, ISSN: 1756-9966, DOI: 10.1186/1756-9966-29-41
HAMELIN CÉLINE, CORNUT EMILIE, POIRIER FLORENCE, PONS SYLVIE, BEAULIEU CORINNE, CHARRIER JEAN‐PHILIPPE, HAÏDOUS HADER, COTTE EDDY,: "Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer", THE FEBS JOURNAL, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 278, no. 24, 1 December 2011 (2011-12-01), GB , pages 4845 - 4859, XP093097457, ISSN: 1742-464X, DOI: 10.1111/j.1742-4658.2011.08385.x
ABI ZAMER BATOUL, EL-HUNEIDI WASEEM, ELADL MOHAMED AHMED, MUHAMMAD JIBRAN SUALEH: "Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives", CELLS, vol. 10, no. 11, pages 2862, XP093097462, DOI: 10.3390/cells10112862
RUAN WENJING; WANG YINGHONG; MA YU; XING XIAOMING; LIN JIE; CUI JING; LAI MAODE: "HSP60, a protein downregulated by IGFBP7 in colorectal carcinoma", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, BIOMED CENTRAL LTD, LONDON UK, vol. 29, no. 1, 30 April 2010 (2010-04-30), London UK , pages 41, XP021083448, ISSN: 1756-9966, DOI: 10.1186/1756-9966-29-41
HAMELIN CÉLINE, CORNUT EMILIE, POIRIER FLORENCE, PONS SYLVIE, BEAULIEU CORINNE, CHARRIER JEAN‐PHILIPPE, HAÏDOUS HADER, COTTE EDDY,: "Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer", THE FEBS JOURNAL, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 278, no. 24, 1 December 2011 (2011-12-01), GB , pages 4845 - 4859, XP093097457, ISSN: 1742-464X, DOI: 10.1111/j.1742-4658.2011.08385.x
ABI ZAMER BATOUL, EL-HUNEIDI WASEEM, ELADL MOHAMED AHMED, MUHAMMAD JIBRAN SUALEH: "Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives", CELLS, vol. 10, no. 11, pages 2862, XP093097462, DOI: 10.3390/cells10112862
Attorney, Agent or Firm:
LEE, Won Hee (KR)
Download PDF: