Title:
ACTIVATOR OF TREK (TWIK RELATED K+ CHANNELS) CHANNELS
Document Type and Number:
WIPO Patent Application WO/2018/110669
Kind Code:
A1
Abstract:
Disclosed is a compound of formula (I): wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds, and methods of using the compounds, compositions and kits for treatment of disorders associated with TREK-1, TREK-2 or both TREK-1 and TREK-2 dysfunction in a mammal.
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Inventors:
LINDSLEY CRAIG W (US)
WIETING JOSHUA M (US)
MCGOWAN KEVIN D (US)
DENTON JEROD S (US)
YASHIRO KENTARO (JP)
KURATA HARUTO (JP)
SEKIOKA YOKO (JP)
MORI TAKAHIRO (JP)
IWAKI YUZO (JP)
WIETING JOSHUA M (US)
MCGOWAN KEVIN D (US)
DENTON JEROD S (US)
YASHIRO KENTARO (JP)
KURATA HARUTO (JP)
SEKIOKA YOKO (JP)
MORI TAKAHIRO (JP)
IWAKI YUZO (JP)
Application Number:
PCT/JP2017/044975
Publication Date:
June 21, 2018
Filing Date:
December 14, 2017
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
UNIV VANDERBILT (US)
UNIV VANDERBILT (US)
International Classes:
C07D471/04; A61K31/277; A61K31/41; A61K31/4245; A61K31/4353; A61K31/4439; A61K31/5375; A61P9/00; A61P29/00; C07C253/30; C07C255/50; C07D257/04; C07D271/06; C07D295/155
Domestic Patent References:
| WO2015163472A1 | 2015-10-29 | |||
| WO2011059048A1 | 2011-05-19 | |||
| WO2007098352A2 | 2007-08-30 | |||
| WO2010100606A1 | 2010-09-10 |
Foreign References:
| US20150166496A1 | 2015-06-18 | |||
| US20140243338A1 | 2014-08-28 |
Other References:
PRASANNA, DADI: "Selective Small Molecule Activators of TREK‑2 Channels StimulateDorsal Root Ganglion c‑Fiber Nociceptor Two-Pore-DomainPotassium Channel Currents and Limit Calcium Influx", ACS CHEMICAL NEUROSCIENCE, vol. 8, no. 3, 2 November 2016 (2016-11-02), pages 558 - 568, XP055499055
DATABASE REGISTRY [o] 24 October 2000 (2000-10-24), retrieved from STN Database accession no. 298684-44-3
LOLICATO, MARCO ET AL., NATURE, vol. 547, 20 July 2017 (2017-07-20), pages 364 - 368, XP085340497
See also references of EP 3558992A4
DATABASE REGISTRY [o] 24 October 2000 (2000-10-24), retrieved from STN Database accession no. 298684-44-3
LOLICATO, MARCO ET AL., NATURE, vol. 547, 20 July 2017 (2017-07-20), pages 364 - 368, XP085340497
See also references of EP 3558992A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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